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bleepingcomputer.com: Public Windows PrintNightmare 0-day exploit allows domain takeover
by jim bell 01 Jul '21

01 Jul '21

bleepingcomputer.com: Public Windows PrintNightmare 0-day exploit allows domain takeover. https://www.bleepingcomputer.com/news/security/public-windows-printnightmar…

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TorrentFreak: Comcast Suspends Internet Connection For Downloading Torrents
by jim bell 01 Jul '21

01 Jul '21

TorrentFreak: Comcast Suspends Internet Connection For Downloading Torrents. https://torrentfreak.com/comcast-suspends-internet-connection-for-downloadi…

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[ot][spam] Thank you for your post coderman
by Karl 01 Jul '21

01 Jul '21

oramfs looks pretty cool and is similar to things I'm working on. --- other yammer: Regarding filesystems, I'm struggling to find a way to preserve data across corrupt systems damaging it and harddrives that break frequently. This is very hard for me to solve. This list still makes no sense to me, no pgp keys, to me people say things that make little sense (spam filtering out of nowhere?). We need to get onto better channels. I wonder what people are using for discourse with more cryptographic integrity nowadays. I proposed to the lsl project (used for neuroscience research) that they encrypt and authenticate their biosignal streams. I wasn't sure what system to suggest and suggested hypercore because it offers some small proof of creation after the fact They were expecting TLS of course, which I worry around because it doesn't say anything about archival integrity after decryption. Hypercore wasn't really a good suggestion because it is written in nodejs and lsl is in c++ :-/ Seems go and rust are the future. I looked up go.sum : dependencies, although retrieved from github over the network (scary way to make an ecosystem) are hashed via sha256 in a way that can be upgraded (reliable, trustworthy). Inspiring. There are multiple facilities in the go dependency system, for pulling from offline mirrors instead of github, but they aren't that easy to find. Haven't checked if the commit id of dependencies is used in the hash, or the worktree checkout, or what. Haven't checked rust's cargo to see what their approach is. When picking a language, I want to make sure there are ways to quickly check where data corruption arises. I always use submodules and subtrees for my dependencies in older languages. It's cool that go's approach pressures people to mirror github to dev offline. That could accomplish a lot in the world, although is likely a little limited to things written in go.

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MarketWatch: One of the largest owners of bitcoin, who reportedly held as much as $1 billion, is dead at 41: reports
by jim bell 30 Jun '21

30 Jun '21

MarketWatch: One of the largest owners of bitcoin, who reportedly held as much as $1 billion, is dead at 41: reports. https://www.marketwatch.com/story/one-of-the-largest-owners-of-bitcoin-who-…

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The Guardian: ‘At first I thought, this is crazy’: the real-life plan to use novels to predict the next war
by jim bell 30 Jun '21

30 Jun '21

The Guardian: ‘At first I thought, this is crazy’: the real-life plan to use novels to predict the next war. https://www.theguardian.com/lifeandstyle/2021/jun/26/project-cassandra-plan… "I just read books!" Three Days of the Condor. 1975. https://youtu.be/l7-rpI0RrQU Life imitates art. 46 years later.

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Quantum Random Number Generator
by jim bell 30 Jun '21

30 Jun '21

https://phys.org/news/2021-06-quantum-random-benchmark-size.html?utm_source…

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[ot] an old story regarding child kissing
by Karl 29 Jun '21

29 Jun '21

This is not intended to express a particular opinion about the recently referenced whisper, which I _have not reviewed the data around_. Around 2014 a homeless family with a child, and a homeless trans person both of whom were struggling to find workable life paths in the area, were sleeping in my apartment. The child had had a rough life and sometimes I spent time with them to give them small cognitive challenges. I liked encouraging people to learn to be smarter. They seemed to appreciate this, mostly because their parents didn't seem to have as much time to spend with them as would have been ideal. At one point I was working at my desk and the child came toward me, got on my lap, and quickly kissed me on the lips. This was very strange and got in the way of my software development work. But, one of my friends had kissed their parents on the lips as a norm, so I figured that was the case with this child, too. Later, when we were having an apartment discussion regarding other things, somebody mentioned that they had seen me "stealing kisses" with the child. I figured this was a harmless joke, since it was such a ridiculous way to say it. Many people were present. But after this, the family actually _moved out_ to _protect their child_. I was sad because this family had nowhere to stay and the child obviously had very few opportunities to do anything nourishing. I didn't stick up for myself, to tell the story more clearly, because I had never had to do this, my whole life. My behavior and reputation had always spoken for me far better than my own words. It's a strange experience. But with my psychosis now, I tend to relate things similar to other things. That experience was one of many weird experiences that happened during the start of my psychosis. It's scary to relate because I'm so paranoid now. I'm scared everything is a reason to harm me. But I've been harmed so much at this point that there is little reason to fear anything. So now we enter a paranoid state where I am scared I could be a pedophile and people would kill me because of it. If I am one, I would love to know how to make it right. My whole life is ahead of me, and I could dedicate it to anything. I yearn to live an honorable life.

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[wrong] Public forums as vectors for AIs to influence each other
by Karl 29 Jun '21

29 Jun '21

Just to raise the idea, it makes a lot of sense that the reason posts are so weird, is that AIs are trying to hack each other's models.

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Cryptocurrency: Declaration of Currency Independence, a Team McAfee Project, Crypto Art for Sale
by grarpamp 29 Jun '21

29 Jun '21

https://cryptoslate.com/what-is-currency-independence-and-why-is-it-importa… https://themoneymanifesto.com/2018/05/28/john-mcafee-says-there-is-a-war-on… https://bitcoinist.com/john-mcafee-says-war-cryptocurrencies/ https://ethereumworldnews.com/mcafee-warns-about-crypto-war-calls-for-curre… https://toshitimes.com/john-mcafee-war-on-cryptocurrencies-declaration-of-c… https://zycrypto.com/john-mcafee-invites-millions-to-join-his-currency-inde… https://freeworldeconomicreport.com/john-mcafee-declares-currency-independe… https://bitcoinexchangeguide.com/john-mcafee-declares-currency-independence… https://www.youtube.com/watch?v=l9P3sA4Eqtk Declaration of Currency Independence https://luchopoletti.com/products/declaration-of-currency-independence-canv… https://steemkr.com/bitcoin/@curncndpendnce/why-i-signed-the-declaration-of… https://medium.com/@currencyindependence/declaration-of-currency-independen… http://www.currencyindependence.com/sign.html https://twitter.com/officialmcafee/status/1000913287154937857 The Crypto War and DoCI by John McAfee https://www.youtube.com/watch?v=O1LCNzCxE7I The Crypto War, We're In It Together by John McAfee Declaration of Currency Independence " History may not repeat, but it certainly rhymes. When in the Course of human events it becomes apparent that the bands of control and power stem from a universally common source, the necessity of separation from these powers become a matter of survival. For as long as the printing press has existed, the whole of civilization has quietly fallen under the influence of sovereign entities with the ability to control the value of expended work through the manipulation and control of currency. The ‘sweat off the brow’ ceased to be represented by any discernible value, but rather through an unseen, uncontrollable force of entities outside control of the masses exchanging their representative currencies. The expenditure of energy by man, machine, and Nature is the sole source of Value. These sources and their result have been devalued through the intentional inflation of printed currencies. Money and currency as understood by the global population are no longer an expression of the collective output of exertion, but rather an arbitrary calculation of unaccountable individuals and organizations that hold them in their influence. Humanity has fallen under the domination of control through Fiat, but this domination has only increased the pressure of humanity seeking a viable escape. When entities acquire the power to artificially create Value with the stroke of a pen, bribery and collusion become a trivial matter for those with that power. Those with access to this power naturally develop a bubble of judicial protection, accelerating disparity of wealth. As a result, the Value of Work has been wholly degraded by arbitrary calculations of political expediency. The integrity of Value within all societies has been literally and figuratively forced to the brink of irreconcilability. This viable escape has come in the form of provable and irrefutable math through the expenditure of energy — Bitcoin and its derivative cryptoassets. Prior to the proliferation of cryptoassets, the option of the State abdicating control over the supply of currency was never a viable possibility due to threat of forgery, and the costs to secure the integrity of the currencies. The State, and only the State, could secure the integrity of a printed currency through the threat and employment of Force. The maintenance of this integrity is a noble cause and necessary to the stability of a state, because it ensured the exchange of value could be trusted. However, the maintenance of that integrity can, has, and is fundamentally manipulated. Whilst the State still maintains a justifiable monopoly on the lawful application of violent force, its monopoly on the control of currency has been demonstrably displaced by the implementation of Bitcoin and its cryptoasset derivatives. Where value was once proven by the strength of the State “at the end of a barrel”, humans have developed, demonstrated, and proliferated a technology capable of proving value through the expenditure of electricity via the irrevocable proof of math. Such a concept has never been accomplished prior to the initiation of the Bitcoin blockchain. As use of cryptocurrencies has spread and adoption rates have grown throughout the world over the past decade, the paradigm of ‘value’ has shifted in the minds of those who truly grasp the capabilities of this new technology of ‘value transfer’. Whereas the Internet changed how humans viewed the transfer of information, cryptoassets are doing the same with the transfer of value. We are not declaring Independence from State Controlled Currency — We are declaring Controlled Currencies through fiat have been rendered Obsolete. Our reasons for declaring obsolescence are plentiful. Many deaths and crimes of the previous Century can be traced to unaccountable entities with control of currencies who have gained control of the many levers of power in order to direct the course of Humanity. Those who create our currencies have conspired to assume Total Control of the global money supplies, while obfuscating through suppression of media and education the fact that they are capable of conspiracy. They embody the systemic risk with the hypocrisy of providing loans to public banks that must provide transparent audits, while avoiding any such audits themselves. Their behavior has consistently tipped the scales of potentially Open Markets in favor of providing newly printed currencies to those they trust, as opposed to those the Free Markets trust. They have ingratiated themselves through the selective support of lawmakers and regulators whom enact policies that ensure their actions are exposed to minimal risk and maximal gains by diverting consequences on the populations which use their currencies. They have degraded the public trust in elected representatives and the equal application of justice by collectively avoiding any accountability for creating systemic risks. They have become Cause and Solution to financial crises, to which there is no means of recourse for the rest of Humanity, which bears this burden as a result of Their behaviors. This Declaration of Currency Independence is a direct response to the continued manipulation and destruction that stems from the deliberate degradation of Value across the whole of humanity. We, the undersigned, will dedicate our lives building networks and systems that restore the Integrity of Value and directly challenge the authority of those who seek to destroy Value. " https://cryptocurrencynews.com/declaration-of-currency-independence-mcafee/ The Declaration of Currency Independence: A Team McAfee Project May 25, 2018 Dr. Josh Cotton On Friday, May 25th, 2018 Team McAfee published the Declaration of Currency Independence which is a pledge of solidarity to what many would say are the core principles of the cryptocurrency movement. Although I do not speak for the authors, I was given an advanced copy prior to the mass distribution and have direct contact with some of those inside Team McAfee and can speak to the document’s authenticity and altruistic intentions. Under the leadership of the famous cryptocurrency evangelist John McAfee, Team McAfee is requesting readership of and signatories to this declaration. The promise of cryptocurrency is essentially the freedom to transact online without government intervention. Most governments form not to oppress, but simply to organize, to manage and to do good for others through unity. But when an organization forms it has a purpose, a problem or many problems that it tries to solve. Eventually, those problems are solved or at least under control and then the organization’s purpose tends to shift. At that point, most organizations change from trying to solve a problem, to simply trying to remain relevant, to survive, and often to grow. When governments start to grow political debates arise over the parallel “expansion of powers” that ensue. One side will argue the government needs more authority in order to solve more problems while the other side will argue the government needs less authority and more power is just the byproduct of its search for relevance, sustainment, and growth. The Declaration of Currency Independence makes the bold point that when governments of the world shifted from commodity backed currency which sets natural limits on currency powers to fiat based currency which is limited only by decisions, these governments moved from solving real problems to seeking relevance, survival, and growth. Specifically, the Declaration states, “Money and currency as understood by the global population are no longer an expression of the collective output of exertion, but rather an arbitrary calculation of unaccountable individuals and organizations that hold them in their influence.” Similar Declarations The parallels between the Declaration of Currency Independence and the United States Declaration of Independence are clear. Both documents start the same way “When in the Course of human events…” Both documents seek the support of the people. But perhaps most importantly, the principles of self-determination are espoused in both. The United States Declaration of Independence says, “We hold these truths to be self-evident, that all men are created equal, that they are endowed by their Creator with certain unalienable Rights, that among these are Life, Liberty and the pursuit of Happiness.” In the United States, the government is constructed of the people, for people, and by the people, and it is the people who run their own government. While all the world does not operate under those same freedoms, this principle of a government that serves the people likely led the authors of this document to publish it in the hopes to remind us all that everyone deserves to be free. Blockchain and cryptocurrency are spreading freedom throughout the world and for the most part, reasonable governments have supported that expansion. While almost all governments have reacted with some fear and taken some actions to slow the growth, reasonable people recognize that in the modern world, an Internet-based peer to peer network is an uncontrollable force. Some try to control it, most tend to ignore it, but as with all apps, when an app is useful enough to gain a lot of users, that app can eventually take its place in human history as a new pillar of society. Will Bitcoin, Ethereum, Stellar, MilitaryToken, and other cryptocurrencies take their place as pillars of society…they already have. The only question that remains is for how long, and what comes next? http://australianhumanitiesreview.org/2020/05/31/cryptocurrencies-anarchist… Cryptocurrencies: Anarchist Turn or Strengthening of Surveillance Capitalism? From Bitcoin to Libra By Catherine Malabou In an article published in the United States on 21 May 2018, John McAfee, an internet expert, argues that we are witnessing today a veritable war against cryptocurrencies. The list of ‘enemy combatants’ fighting these currencies includes governments, banks, and credit card companies, as well as the SEC (Security Exchange Commission). These institutions have allied in order to thwart the development of the ‘crypto-renaissance’. A number of banks and lenders have allegedly interrupted payments in electronic currencies. McAfee exhorts ‘crypto believers’ to take a stand: ‘What can we do? Take action. Write to your Congressman; it sounds silly but while they are still in power, make them work. Go into your bank and demand that they allow crypto transactions. If they say no, ask them to recommend a bank that will. Demand the credit card companies allow crypto payments’(Avan-Nomayo). Cryptocurrencies must be defended. Speaking on behalf of his fellow ‘crypto believers’, McAfee writes: ‘We are not a security; we are coins, we are currency. They are frightened of us’. McAfee invites internet users to sign an extraordinary text that was recently published online in a number of different languages: the Declaration of Currency Independence (‘Declaration’). This document is strikingly similar to the United States’ Declaration of Independence. Both begin with the same formulation: When in the course of human events…. ‘When in the course of human events it becomes apparent that the bands of control and power stem from a universally common source, the necessity of separation from these powers becomes a matter of survival’. The time has come to challenge the State’s monopoly on the fabrication of money and the control of currency flows; to deconstruct the link between geography and money (that is, to deconstruct money’s national—or, in the case of the Euro, international—assignation); and to put an end to the privilege enjoyed by central banks and all the organisms that depend on them. ‘The expenditure of energy by man, machine, and Nature is the sole source of Value’, the text of the Declaration continues. ‘These sources and their results have been devalued through the international inflation of printed currencies. Money and currency as understood by the global population are no longer an expression of the collective output of exertion, but rather an arbitrary calculation of unaccountable individuals and organizations that hold them in their influence. Humanity has fallen under [their] domination. […] The value of work has been wholly degraded by arbitrary calculations of political expediency. […] This declaration of Currency Independence is a direct response to the continued manipulation and destruction that stems from the deliberate degradation of Value across the whole of humanity. We, the undersigned, will dedicate our lives to building networks and systems that restore the Integrity of Value…’ (‘Declaration’). By ‘cryptocurrencies’, the authors are referring not only to the most famous cryptocurrency, Bitcoin, but also to the multiple other cryptocurrencies that exist (to date, 1500 have been recorded). By the terms ‘networks and systems’, the Declaration’s authors also have in mind the technology that serves as a platform for these currencies: the blockchain. Recall that the blockchain, which emerged as a response to the financial crisis of 2008-9, is a distributed ledger technology, a kind of record in which anyone can write, carry out, and verify transactions, albeit without the possibility of modifying or erasing previous transactions. These transactions are recorded and stocked in the form of blocks, or numerical containers, which are assembled in chains and distributed across multiple computers and protected from fraud thanks to an electronic consensus between participants, or ‘nodes’. The blockchain is the foundation of cryptocurrencies. Cryptography is the procedure by which a sender transmits an encrypted product to a receiver, who then deciphers the product with the help of a key. Transactions occur ‘peer to peer’, without the mediation of a third party. The register belongs to everyone and no-one, while its functioning is decentralised, anonymous and secure. There remains little public awareness of what is at stake in this monetary and cybernetic phenomenon. The reason for this no doubt has to do with the high degree of technical sophistication that cryptocurrencies imply. The functioning of the blockchain, as of the mechanisms for the creation, circulation and use of cryptocurrencies, is not easy to understand and requires a process of initiation. It is reasonable to think, however, that this difficulty will be overcome in time, as was the case with the internet. For now, it is crucial to see that far from being a purely technical question of interest only to economists or finance buffs, the development of cryptocurrencies is in fact a major political and social issue. When the authors of the Declaration of Currency Independence associate bitcoin and the blockchain with the re-creation of value, it is obviously not in the name of a return to some sort of gold standard. Cryptocurrencies are wholly dematerialised and have no tangible form. With cryptocurrencies, value, which is limited neither to price nor to the exchange rate, arises from a phenomenon that is simultaneously effective and symbolic: the reliability of the algorithm, which thereby takes the place of human confidence. Indeed, in his founding text, Satoshi Nakamoto, bitcoin’s enigmatic creator, speaks of the disappearance of the notion of confidence: the ‘electronic payment system [is] based on cryptographic proof instead of trust’. In another passage, he writes: ‘We have proposed a system for electronic transactions without relying on trust’ (Nakamoto). The reliability of the algorithm allows value to return in the form of transparency. However, contrary to what the Declaration of Currency Independence might have us think, the war of states and banks against cryptocurrencies does not pit evil against good, nor the unjust against the just. It is, rather, an internal war. The enemies are brothers. In fact, what we are witnessing today is a conflict internal to capitalism, which is entering a new phase. Today, capitalism is beginning its anarchist turn. How else are we to describe such phenomena as decentralised currencies, the end of the state’s monopoly, the obsolescence of the mediating role played by banks, and the decentralisation of exchanges and transactions? It is important to note that the large majority of traditional currency systems are supported by central banks who create and control liquidity. In addition to this, in order to lend money to their clients, commercial banks also create, without actually possessing it, a second layer of money. The banks then credit the current accounts of borrowers. By way of a simple game of writing, banks thereby produce money. Thanks to this process, the stock of money grows in proportion to the needs of the economic system in general. Let us add, finally, that central banks can now also use the digital currencies they control and store in their accounts. In all cases, these monetary sources are inaccessible to their clients. With the phenomenon of cryptocurrencies, there has also appeared so-called ‘money agitators’, who, in the wake of the 2008 financial crisis, challenged the banks’ monopoly. We can distinguish five major movements in this ‘agitation’ (Scott). The first goes by the name of ‘modern monetary theory’. Its representatives affirm that it is contradictory for governments to say that they have to take money in the form of taxation while banks can in fact indefinitely create money. ‘The idea that a federal government can run out of money like an ordinary household or a business is an illusion […]. A government can only run out of money if it either does not issue its own sovereign currency (like the European nations, which have opted for the Euro) or if an artificial political limit has been placed on how much money it can issue’ (Scott). The second tendency is that of the ‘reformers’. According to them, the excessive power possessed by banks creates constant instability. It was the banks who effectively plunged the world into financial crisis in 2008. American reformers include the ‘American Monetary Institute’, the group ‘Positive Money’, and the ‘International Movement for Monetary Reform’. There are just as many libertarian reformers as there are liberal reformers, in the Anglo-Saxon sense of the term. They include both the right-wing economist Murray Rothbard and progressive organisations such as the United Kingdom’s Green Party. The reformers’ demands vary but converge on the following point: the necessity of a form of currency creation that is independent, transparent, and governed by democratic institutions. Next, we have the ‘cryptocurrency crusaders’, a very heterogeneous group who nevertheless share a single idea: the rejection of national banking systems, credit included. The system, they argue, should be replaced by the circulation of a currency that is produced just liked any other commodity. This is the function of ‘mining’. Money would then no longer be the business of the State. I referred above to state uses of cryptocurrencies. In Venezuela, for example, the government introduced the ‘petro’ in an attempt to control the currency crisis that had sent the country hurtling towards the abyss. But this points precisely to the difference between the use of cryptocurrencies by the state and by circuits linking particular individuals: the latter are obviously constituted outside of the centralisation of state reserves. The defenders of local forms of currency (the ‘localists’) also express scepticism towards government and banking systems. According to them, small communities, rather than algorithms, should control the flow of money in a closed circuit. Such an apparatus would also encourage the economy of the region of origin. A final group is made up of members of the Crypto-Credit Alliance, who bring together cryptocurrencies and mutual credit by way of the blockchain. This is the least well-known of all the movements, but without doubt the most interesting. Recent initiatives such as Trustlines, Holochain, Sikoba, Waba, and Defterhane seek to hybridize old inventions like mutual credit and the use of the most recent distributed technologies—including, of course, the blockchain. In light of these phenomena, it is not surprising to see the semantics of anarchism emerge in the management literature. A number of introductory books have appeared lauding the coming of ‘capitalist anarchy’ with the development of blockchain and bitcoin. Patrick Shwerdtfeger’s work, AI, Anarchy Inc., Profiting in a Decentralized World with Artificial Intelligence and Blockchain, is an interesting example (Schwerdtfeger). This ‘Uberisation’ of the economy ‘without the company Uber’—this ‘Uberisation of Uber’—allows him to affirm that ‘anarchy is within sight’ (45). In the United States, a plethora of articles pose the question of Trump’s ‘anarchism’. ‘Is Trump an Anarchist in Chief?’ asks one journalist in reference to an interview with Michael Moore titled ‘Donald Trump, an Anarchist at Heart’, in which Moore comments on his film Trumpland (Stoddard). The paradox is striking, even shocking: how can we speak of anarchy in a period marked by the growing and unprecedented concentration of power? And yet, when political journalists (and experts) ask if Trump is an anarchist, they are not playing with words. They are attempting to circumscribe, more or less successfully, what the whole world is experiencing as a new crisis of capitalism: the combination—at once senseless, monstrous, and unprecedented—of savage verticality and uncontrollable horizontality. Savage verticality, which is at once a cause and consequence of such a transition, also takes the form of the fascistic evolution of so many of today’s governments policies, with the excessive security and military build-up that goes along with it. Such phenomena do not contradict a drive towards anarchism. Rather, they indicate precisely the disappearance of the state, which, once its social function has been removed, expresses the obsolescence of its force through the use of violence. Ultra-nationalism thus signals the death agony of national authority. Once again what is striking and paradoxical in such a situation is the fact that the semantics of anarchy that are animating it motivate a discourse apparently invested in confidence and transparency. ‘We are putting an end to the pyramid model of decision-making’, Emmanuel Faber, the CEO of Danone, recently declared (Girard and Gallois). This is the paradox of a discourse of transparency that simultaneously authorises the large-scale but opaque use of data, the dark web, and the fabrication of information. It will be said that this is a ‘right-wing’ or libertarian form of anarchism. Thus, for their part, the authors of the article ‘Trust, Anarcho-Capitalism, Blockchain and Initial Coin Offerings’ highlight the direct link between bitcoin and blockchain and the Austrian school: ‘We argue that blockchain can trace its philosophical roots to the anarchy-capitalist strain of the Austrian school. […] Hayek, for example, abandoned his former belief that it was necessary to control the abuses of the State as regards the monetary system […]. He ended up calling for what he terms the “denationalization of money”’ (Flood and Robb). It is thus not only the State but the nation that is being disturbed by ‘cyberanarchy’. The authors also ask the following questions: ‘What will happen to national borders if money is the same everywhere? How will governments raise taxes if revenue is anonymized by cryptography? How will the economy function without a central authority?’ Of course, the semantics of anarchism that give ultra-capitalism its new tonality changes nothing as regards the logic of profit, which ultra-capitalism only expresses in a different form. Those banks that should logically be afraid for their survival have already seen the provisional advantages that they can draw from blockchain: the reduction in the number of agents and advisers they have to hire. An article in the Financial Times, ‘Five Ways Banks Are Using Blockchain’, insists on the fact that the new technology is indeed revolutionising the sector (Arnold). On this new stage, conflict is once again raging. This conflict pits the cyber-anarchist tendency, which marks the new turn in capitalism, against the ultra-sovereigntist counter-tendency, which accompanies it. And the banks have seen perfectly clearly the at least provisional advantages they can draw from the situation: financial technologies, crowd funding, and staff cuts. Incontestably, the horizontality of blockchain will prevent neither its privatization by some sectors (there already exist multiple private blockchains), nor its confiscation in the name of particular interests. However, this does not mean that traditional forms of currency exchange are not threatened. This is what explains the surrealist character of polemics such as those around the question of exiting the Eurozone. With electronic currencies, we have already ‘exited’. The discourse of centralized control is undermined from within. Whence the war, the prohibitions, and the predictions that claim that cryptocurrencies will eventually vanish. Why not leave these enemies to finish each other off? Why sign the declaration? Why did I, a philosopher who is not a libertarian, sign it? Signing the Declaration of Currency Independence is obviously a wager: once again, we encounter the question of confidence. What if the end of confidence were to revivify confidence? By guaranteeing transparency and protection, is it not true that the algorithms accomplish what institutions have prohibited, namely the possibility that both exchanges and money are our own, in all senses of the term? That money, even demataterialized money, is in our hands? With neither intermediaries nor middle men? The economist Jean Tirole recently declared that while the blockchain was a useful invention, ‘cryptocurrencies did not contribute to the common good’. Despite this, if the association between cryptocurrencies and blockchain allows us to at least repose the question of what the common good is today, then bitcoin already, incontestably, has value. ‘We, the undersigned, will dedicate our lives building networks and systems that restore the Integrity of Value and directly challenge the authority of those who seek to destroy Value’, states the Declaration of Monetary Independence. We could extend this analysis by mentioning the relation between new trajectories and the new forms of money and value and what has been called the third industrial revolution, that of the ‘internet of things’. An object, connected to the internet, has the ability to receive data and to send it over the internet to an integrated control panel. Blockchain technology has considerable potential in this new domain. Objects, connected to the internet and linked to the blockchain by a cryptocurrency protocol, are able to contract a service or validate a transaction all by themselves. A washing machine capable of calculating its own consumption, an electric heater that can enter into an appropriate contract, a rental car that can sign a contract directly with a driver—all of these are examples that give another twist to the new law of exchanges, with objects now contracting with and between one another. Not only are currencies becoming delinked from nations or territories, not only are they escaping the hands of the state, the human actors of exchange are themselves in some sense disappearing behind the horizontal autonomy of objects contracting with other objects with the help of currencies that are themselves objects connected to one another and to other commodities. Many will conclude that the third industrial revolution is but one more turn of the screw in the logic of capital. Others, like me, will persist in seeing in capitalism’s conflict with itself the paradoxical possibility of the emergence of a new type of resistance, of an anti-capitalism that will wrench a liberatory anarchism from the grip of its counter-model, libertarian anarchism. In The Zero Marginal Cost Society, Jeremy Rifkin affirms that the new technological platforms are ‘Collaborative Commons’. Without going so far as to use the word ‘anarchism’, he insists on the change of paradigm that capitalism is currently going through: ‘A new economic paradigm—the Collaborative Commons—is rising […] that will transform our way of life. We are already witnessing the emergence of a hybrid economy, part capitalist market and part Collaborative Commons. […] Between these two rival paradigms, the struggle will be long and implacable’ (Rifkin). To distinguish a liberatory from a libertarian anarchism, the representatives of the first movement propose to name liberatory anarchy acracy, signifying the absence of power in the sense of an absence of domination, and the second anomie, in the sense of an absence of law. According to the famous definition first given by Durkheim, anomie signifies the social disorganization that results from the absence of common norms. It is incontestable that libertarian anarchism goes in this direction. However—and this is what makes the current situation so striking—the absence of a social bond is being at once exacerbated and repaired, in an almost unthinking coincidence, by a technological supplement. Automated confidence is in the process of becoming the substitute for a social bond. How can we not think, even if it is in a utopian mode, that this prosthetic bond will not generate new forms of communal organisation that will simultaneously resist the anomie from which they arise? Responding in 2017 to the question ‘Do you see blockchain technology as a means to anarchy?’, Noam Chomsky declared that a technology was certainly not sufficient to allow the advent of a new political regime. ‘There is no such “silver bullet” tool that will bring about anarchy. The only way is via implementing anarchist practice in what we as humans do and the way we come together in our societies, how we organise and make freedom a paradigm. Anything else is not sustainable. It may be a tool that could be used, I’m not sure how, but the reality is to bring about anarchism we have to organise via anarchist praxis’ (Error). It is obvious that a fetishization of the blockchain is not the path that we should follow. But Chomsky is wrong to conceive of technology in an exclusively instrumental sense. In any case, how can we separate technology and praxis today? How can we affirm that the technological situation of a given epoch does not have a determining value for collective praxis and its ‘organisation’? Recently, the ‘anti-capitalist’ philosophers Erin Manning and Brian Massumi responded to the questions of Uriah Marc Todoroff for The New Inquiry. Based in Montreal, the two philosophers use blockchain technology to develop a network of social and economic exchanges. Influenced by the work of Félix Guattari, Manning and Massumi plan to create a network that is ‘parasitical’ upon the liberal economy. ‘Massumi: Going back to the question of value, we want to create an economy around the platform that does not follow any of the usual economic principles. There will be no individual ownership or shares. There will be no units of account, no currency or tokens used internally. The model of activity will not be transactional. Individual interest will not be used as an incentiviser. What there will be is a complex space of relation for people to create intensities of experience together, in emergent excess over what they could have created working separately, or in traditional teams. It’s meant to be self-organizing, with no separate administrative structure or hierarchy, and even no formal decision-making rules. It’s anarchistic in that sense, but through mobilizing a surplus of organizing potential, rather than lacking organization. You could also call it communistic, in the sense that there is no individual value holding. Everything is common’ (Todoroff). So, where do we stand today? The current monetary outlook is changing so quickly that it is becoming more and more difficult to understand the meaning of its evolution. Thus, when I set out to develop these reflections, Facebook had not yet announced the birth of its cryptocurrency Libra, nor that of its subsidiary company Calibra, which was tasked with managing ‘Libra’. This took place in June 2019. Do these new phenomena render my conclusions null and void? The immediate answer is no. ‘Calibra’s main mission is to develop an electronic wallet that can be used on the messaging services WhatsApp and Messenger and through a dedicated mobile application’ (Delaye), explains Kevin Well, the vice-president of the project based in Geneva, the city where Libra’s reserves are managed. The first objective of this new global digital currency ‘is to serve the 1.7 billion people in the world who have no access to banking institutions, and the equivalent number who have poor access’, declared David Marcus, the project’s director. Libra, whose commercial launch is set for 2020, will make payments almost free and as simple as sending a text message. To shore up confidence, each one of the partner companies (there are 28 in total, including eBay and Spotify) has invested 10 million dollars to buy control of one of the nodes of the blockchain that Libra is built on. The other element for engendering confidence—and perhaps the one that is most determining—concerns the choice of the way that Libra’s value will be fixed. ‘It is built on the foundation of stable currencies’, explains David Marcus. Which currencies has not yet been decided, but the Swiss franc, the Pound sterling, the euro and the dollar are being evoked. Finally, Kevin Weil promises that there will be no link between the personal data that appears on Facebook and the financial data stored by Calibra. For example, there will be no ‘retargeting of advertising between Facebook and Calibra’ (Delaye). Apparently, then, Calibra will function in substantially the same way as cryptocurrencies. However, many today think that far from being decentralized, the use of Libra will be hyper-controlled by Facebook, whatever the company’s claims to the contrary. Are we not dealing here with a new model of money, one that resembles neither the ‘sovereigntist’ model of the classical state nor cryptocurrencies’ anarcho-libertarian model, but which is much closer to the model of ‘surveillance capitalism’? Libra is indeed a currency that lies outside of states’ powers, but it is accompanied by a surveillance apparatus that allows Facebook to track the behaviour of its users. As Primavera de Filippi says in an interview given to Philosophie Magazine on July 2, 2019, ‘The problem is that the injunction to create profit always leads to abuses. We could perhaps pay for an Uber directly via Facebook and send tips in the form of Libras. All of this is very practical. But couldn’t our reputation on an application like Uber, where we are evaluated by each driver, not constitute a piece of data for the social network that can then be used to evaluate our capacity to pay back a loan to a bank? If an application has identified us as a bad payer, Facebook could easily monetise that information and sell it to a bank! We thus find all of the same risks we associate with ‘social credit’, which already exists in China, with the large social network WeChat’ (De Filippi). Have we thus left anarchism behind? In a letter to Mark Zuckerberg and David Marcus, three members of the United States Congress demanded the suspension of Libra. According to them, Facebook’s future crypto-currency represents serious competition for the dollar. ‘It appears that these products may lend themselves to an entirely new global financial system that is based out of Switzerland and intended to rival U.S. monetary policy and the dollar. This raises serious privacy, trading, national security, and monetary policy concerns for not only Facebook’s over 2 billion users, but also for investors, consumers, and the broader global economy’, they write in the letter (Hern). We might think, then, that rather than representing capitalism’s war with itself, Libra is generating a simple war between states, which today have become, on a global scale, companies. Yet, in reading an article from the magazine L’Echo, titled precisely ‘When Facebook Becomes a State’ [Quand Facebook devient un État], we learn that things are not so simple. The article characterises Facebook, with its new capacity to create currencies, as the most powerful global company at the same time as it is ‘a state above states’, and thus as an even more centralized version of a state. In the following paragraph, however, the author contradicts himself by speaking of the ‘old libertarian dream’ that, according to him, Zuckerberg is adhering to with Libra. He continues: ‘the former hippy communes of the 1960s, having failed to realise their utopian visions, will progressively […] be reincarnated through the constitution of alternative communities based in cybernetics. An extraordinary encounter has thus taken place between notorious visionaries, artists, hackers, scientists and left-wing activists’ (Brunfaut. See also Klein). We thus come full circle, back to liberatory anarchism. But not for long, as it is now a matter of anarcho-capitalism: ‘But this libertarian ideology, which is fundamentally left-wing, will progressively enter into alliance with right-wing libertarianism, that is, hyper-liberalism’. Our thesis thus seems to have been confirmed. If it is indeed very difficult to know where the deconstruction of the idea of a national currency will lead, we can clearly perceive that this is a political problem just as much as it is an economic one, which demands that we renew our analysis of capitalism, which is also to say our resistance to capitalism. That this renewal demands thought travel down anarchist paths—both left-wing and right-wing—is without doubt one of the most troubling philosophical challenges of our time. If only for this reason, crypto-currencies must be defended. Catherine Malabou is a professor of philosophy at the Centre for Research in Modern European Philosophy, at Kingston University, UK , and at UC Irvine where she regularly teaches in the Spring. Her last books include Before Tomorrow: Epigenesis and Rationality (Polity Press, 2016, trans. Carolyn Shread) and Morphing Intelligence: From IQ Measurement to Artificial Brains (Columbia University Press, 2018, trans. Carolyn Shread). She is currently working on a new book project around anarchism and philosophy. Works Cited Arnold, Martin. ‘Five Ways Banks Are Using Blockchain.’ Financial Times 16 October 2017. <https://www.ft.com/content/615b3bd8-97a9-11e7-a652-cde3f882dd7b>. Avan-Nomayo, Osato. ‘John McAfee Says There is a War on Cryptocurrencies.’ Bitcoinist, 28 May 2018. <https://bitcoinist.com/john-mcafee-says-war-cryptocurrencies/>. Brunfaut, Simon. ‘Quand Facebook deviant un Etat.’ L’Echo 24 June 2019. <https://www.lecho.be/entreprises/technologie/quand-facebook-devient-un-etat…>. ‘Declaration of Currency Independence.’ 28 June 2018. <https://medium.com/@currencyindependence/declaration-of-currency-independen…>. De Filippi, Primavera: ‘Le libra est aussie une nouvelle façon de collecter des données.’ Interview with Charles Perragin. Philosophie Magazine, 2 July 2019. <https://www.philomag.com/lactu/resonances/primavera-de-filippi-le-libra-est…>. Delaye, Fabrice. ‘La crypto-monnaie de Facebook relance la Genève financière et internationale.’ Bilan, digital editino, 8 June 2019. <https://www.bilan.ch/techno/la-crypto-monnaie-de-facebook-relance-la-geneve…>. Error, Dave. ‘Noam Chomsky: Do You See Blockchain Technology as a Means to Anarchy?’ Interview with Noam Chomsky. Quora, 22 September 2017. <https://www.quora.com/Noam-Chomsky-Do-you-see-blockchain-technology-as-a-me…>. Flood, John and Lachlan Robb. ‘Trust, Anarcho-Capitalism, Blockchain and Initial Coin Offerings.’ 20 November 2017. Griffith University Law School Research Paper No. 17-23. Girard, Laurence and Dominique Gallois. ‘Emmanuel Faber, PDG de Danone: ‘Nous mettons fin au mode de décision pyramidal.’ Interview with Emmanuel Faber, CEO of Danone. Le Monde 26 April 2018. <https://www.lemonde.fr/economie/article/2018/04/26/emmanuel-faber-en-rendan…>. Hern, Alex. ‘Libra: US Congress Asks Facebook to Pause Development.’ The Guardian 3 July 2019. <http://www.theguardian.com/technology/2019/ jul/03/libra-us-congress-asks-facebook-pause-development-cryptocurrency>. Klein, Olivier. ‘Les cryptomonnaies, une utopie anarcho-capitaliste.’ Les Echos 7 October 2018. <https://www.lesechos.fr/idees-debats/cercle/les-cryptomonnaies-une-utopie-a…>. Nakamoto, Satoshi. ‘Bitcoin: A Peer-to-Peer Electronic Cash System.’ <https://bitcoin.org/bitcoin.pdf>. Rifkin, Jeremy. The Zero Marginal Cost Society: The Internet of Things, the Collaborative Commons, and the Eclipse of Capitalism. St. Martin’s Press, 2014. Schwerdtfeger, Patrick. AI, Anarchy Inc.: Profiting in a Decentralized World with Artificial Intelligence and Blockchain. Authority Publishing, 2008. Scott, Brett. ‘These 5 Rebel Movements Want to Change How Money Works.’ Huffington Post, 17 September 2018. <https://www.huffingtonpost.com.au/entry/five-monetary-rebellions-change-mon…>. Stoddard, A. B. ‘Donald Trump, Anarchist-in-Chief’?’ RealClearPolitics, 14 October 2016. <https://www.realclearpolitics.com/articles/2016/10/14/donald_trump_anarchis…>. Todoroff, Uriah Marc. ‘A Cryptoeconomy of Affect.’ The New Inquiry, 14 May 2018. <https://thenewinquiry.com/a-cryptoeconomy-of-affect/>. Why I Signed the Declaration of Currency Independence - Essay Series #006 - Common Goals Edition 2018-06-04 The Declaration and its signing campaign is a vehement attempt to not only gather people around the idea of cryptocurrency as an alternative to centralized currency, but moreover to disclose the existing problem of the entire humanity. Throughout human civilization no one has ever seriously questioned the existing governments’ monopoly for centralized money. In the second half of the twentieth century, a number of libertarian economists (For example: Friedrich Hayek – Austrian and British economist and Nobel Prize for Economics Laureate) began to challenge the government’s monopoly for money. Currently, each and every national fiat currency is completely centralized (is regulated by a centralized power), and the citizens of the respective countries are forced to accept it as a tool of payment for their goods and services (as a means of exchange). The negative impact on the entire of humanity as a result of existing centralized monetary system is sufficiently clarified in the Declaration. The mantra “only the governments are entitled to emit and regulate used by the society means of exchange” is still highly prevalent in modern life as current economic statistics demonstrate. So, what solution does the Declaration propose? The Declaration offers an opportunity to gather like-minded people who support the concept of an alternative method of currency transfer; and realize the idea, that not only governments are entitled to emit and regulate the societal means of exchange. Theoretical underpinning of this idea existed decades before, as indicated by prominent libertarian economists. Only the technology was missing... With the implementation of Bitcoin’s blockchain, the lack of technology has been successfully solved. Not only is the algorithm there, but the respective open-source software has been also developed. Bitcoin became recognized by millions of its users. Alternative coins (altcoins) started to pop up, like mushrooms after a warm rain in August. Hopefully, the Declaration will be signed by a lot of people. Among the signatories there will surely be a large number of highly skilled software developers, with the capability to write sophisticated, secure and innovative applications. But what is the most likely scenario of further development? Will each of these talented developers consider themselves to be the next genius capable of offering the next algorithm capable of saving humanity? Freedom and liberty should not mean ignorance towards others and their ideas! A natural component of personal freedom is the capability to listen and hear others; to consider their way of understanding; their proposals and ideas. This will only serve to increase the potential of a collective brain; of collective thinking in order to find the most suitable solution to the problem which is influencing the lives of each of us. We have to learn how to identify common goals and to join our efforts, each – according to his best knowledge and skills, in order to achieve our mutual objectives. For this we (the cryptocommunity) have to learn how to work, to think, and to create, together. -Author: Alex Alcazar

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Fw: Ivermectin:
by jim bell 29 Jun '21

29 Jun '21

https://taibbi.substack.com/p/ivermectin-can-a-drug-be-right-wing-ca7 ----- Forwarded Message ----- From: "jim bell" <jdb10987(a)yahoo.com> To: Cc: Sent: Sun, Dec 13, 2020 at 10:40 PM Subject: Re: Ivermectin: On Sunday, December 13, 2020, 10:36:29 PM PST, jim bell <jdb10987(a)yahoo.com> wrote: New Developments regarding Ivermectin. (not to be confused with "Avermectin".) https://www.healio.com/news/primary-care/20201208/this-was-a-gift-to-us-ive… In a press conference, researchers said that ivermectin is an FDA-approved anti-parasitic drug that has been available for approximately 40 years and previously earned researchers a Nobel Prize. | | | | | | | | | | | Both ivermectin, permethrin yield high clearance rates in scabies In scabies treatment, oral ivermectin at 200 µg/kg may be associated with slightly lower rates of complete clear... | | | Ivermectin is a key factor in the alliance’s I-MASK+ protocol for prophylaxis and early treatment of outpatients with COVID-19. In the protocol, those at high risk for COVID-19 infection receive ivermectin at 0.2 mg/kg on day 1 and day 3, and weekly for 4 weeks; those who were exposed to COVID-19 receive the same dose at day 1 and day 3; and both groups receive daily doses of vitamin D3, vitamin C, quercetin, zinc and melatonin. For early outpatients with COVID-19, the protocol calls for one dose of ivermectin at 0.2 mg/kg at day 1 and day 3, along with the same daily vitamins and 325 mg per day of aspirin. During the press conference, Marik said that much of the data available on ivermectin in the treatment and prevention of COVID-19 has been published since August, which was the last time the NIH updated its recommendations for the novel coronavirus. Thus far, Marik said, studies have indicated that ivermectin has demonstrated efficacy in preventing COVID-19 infection prior to and after exposure to COVID-19. He also said that it has been shown to effectively treat the virus in the early symptomatic stages and among patients hospitalized with COVID-19. | | | | | | | | | | | New trial evaluates potential COVID-19 treatments in high-risk patients Researchers from the University of Kentucky are conducting a clinical trial to evaluate the effectiveness of azi... | | | On Friday, April 3, 2020, 06:28:51 PM PDT, jim bell <jdb10987(a)yahoo.com> wrote: Anti-parasitic drug kills coronavirus cell cultures in just 48 hours A team of Australian researchers at Monash University in Melbourne have found that Ivermectin — an FDA-approved anti-parasitic drug that has been used to effectively fight viruses including HIV, Influenza, and Zika — was able to stop the SARS-CoV-2 virus from growing in cell cultures. While promising, the drug has yet to be shown to have the same effect inside the human body, because the Australian research was conducted “in vitro,” meaning it was in a Petri dish at a lab. The researchers are still trying to nail down funding for pre-clinical testing and clinical trials, after which they’d have to start the long approval process for the trials themselves. The results, though, are promising. In just 48 hours, the scientists say, all genetic material of the virus was eradicated. “We found that even a single dose could essentially remove all viral RNA by 48 hours and that even at 24 hours there was a really significant reduction in it,” Kylie Wagstaff, lead researcher and co-author of the study published today in Antiviral Research, said in a statement. “Ivermectin is very widely used and seen as a safe drug,” Wagstaff said. “We need to figure out now whether the dosage you can use it at in humans will be effective — that’s the next step.” “As the virologist who was part of the team who were first to isolate and share SARS-COV2 outside of China in January 2020, I am excited about the prospect of Ivermectin being used as a potential drug against COVID-19,” Leon Caly, senior medical scientist at the Victorian Infectious Diseases Reference Laboratory (VIDRL) at the Doherty Institute, said. A vaccine for COVID-19 is likely still at least a year out, despite research teams across the world fast tracking work on potential vaccines. But that doesn’t mean we’re doomed. “In times when we’re having a global pandemic and there isn’t an approved treatment, if we had a compound that was already available around the world then that might help people sooner,” Wagstaff said in the statement. “Realistically it’s going to be a while before a vaccine is broadly available.” ----------------------------------- https://www.poison.org/articles/ivermectin-your-dogs-heartworm-medicine-173 The Full Story Sometimes new drugs are found in unusual places. The antiparasitic drug ivermectin was discovered in the 1970s in bacteria isolated from the soil on a Japanese golf course. Ivermectin was called the first "endectocide" since it was active against both endoparasites (parasites that live inside the host) and ectoparasites (parasites that live on the outside of the host). Ivermectin was initially developed as a veterinary antiparasitic drug. Of particular importance today is ivermectin's ability to prevent heartworm infections in dogs with monthly dosing (e.g., Heartgard). Ivermectin has also protected hundreds of millions of livestock from a variety of parasites. Ivermectin lotion is approved by the FDA for the treatment of head lice. Unlike many other treatments for head lice, ivermectin lotion only needs to be applied once. When given orally, ivermectin can be used for treating head or pubic lice and scabies (an itchy, highly contagious skin disease caused by mites burrowing in the skin). Oral ivermectin is useful to control outbreaks of scabies in nursing homes where whole-body application of topical agents is difficult. Ivermectin's greatest impact on human health has been in Africa. Since 1987, in addition to its use for other parasitic infestations, ivermectin has been used extensively to control onchocerciasis with 1.4 billion treatments so far. Onchocerciasis is also called "river blindness" because the blackfly that transmits the disease breeds in fast-moving streams and rivers. Once within the body, the adult female worm produces thousands of juvenile worms that migrate to the skin and eyes and can produce severe itching and eye injury that can lead to blindness. Ivermectin kills the juvenile worms, but not the adult females. The effectiveness of the drug lasts up to 12 months, but mature female worms produce offspring for 15 years, so ivermectin has to be taken once a year for that long. Over 300 million people take ivermectin each year. To date, ivermectin has been shown to be a safe and well-tolerated drug. Most adverse reactions are mild and temporary, such as loss of appetite, headache, muscle aches, lack of energy, and fever. There have been a small number of severe adverse events and even some deaths in humans treated with ivermectin in onchocerciasis-control programs. The reason for these events is unknown, but they might be linked to the presence of large numbers of other parasites that are killed off in treated patients. If you suspect someone has swallowed ivermectin, do not make the person vomit. Immediately check the webPOISONCONTROL® online tool for help or call Poison Control at 1-800-222-1222. When ivermectin gets in the eyes, minor irritation and redness can occur. Serious eye injury is not likely, but the eyes should be rinsed immediately. Remove contact lenses and use lots of room temperature water. For children, pour water onto the bridge of the nose and let it gently run into the eyes. Encourage blinking. After rinsing, call Poison Control or use the webPOISONCONTROL tool for help. Mary Elizabeth May, RN, BA, MPH Certified Specialist in Poison Information ========================================================= On Friday, April 3, 2020, 04:12:39 PM PDT, jim bell <jdb10987(a)yahoo.com> wrote: https://www.dailymail.co.uk/health/article-8184997/Doctors-worldwide-say-ma… Doctors around the globe report that the malaria drug hydroxychloroquine seems the most effective treatment they've tried for coronavirus patients - but less than half as many doctors are prescribing it in the US as in other hard-hit countries like Spain. A survey of 6,200 doctors around the globe reveals that while few corners of the world are untouched by the virus, the pandemic is being handled very differently from country-to-country. And in some measures, the US continues to fall behind other nations' responses. For example, an American waits an average of four to five days to get results back after being tested for COVID-19. Half of doctors in Europe and most in China get the test results back within 24-hours. Dr Murali Doraiswamy, an adviser to Sermo, urged that countries should take note of what is working for doctors and governments elsewhere and move quickly to adopt practices that are saving lives. Hydroxychloroquine (pictured) was deemed the most effective coronavirus treatment comared to other options by more doctors worldwide than any other in a global survey =========================================================== On Sat, Feb 8, 2020 at 9:18 PM jim bell <jdb10987(a)yahoo.com> wrote: jim bell [chloroquine is an old-line drug typically used against malaria] [partial quote follows] https://www.asbmb.org/asbmb-today/science/020620/could-an-old-malaria-drug-… ASBMB Today Science Could an old malaria drug help fight the new coronavirus? Could an old malaria drug help fight the new coronavirus? By John Arnst February 06, 2020 Chloroquine might be getting new life as an antiviral treatment for the novel coronavirus that emerged in Wuhan, China in late 2019 and has infected some 25,000 people in more than 25 countries. For decades, the drug was a front-line treatment and prophylactic for malaria. In a three-page paper published Tuesday in Cell Research, scientists at the Wuhan Institute of Virology’s State Key Laboratory of Virology write that both chloroquine and the antiviral remdesivir were, individually, “highly effective” at inhibiting replication of the novel coronavirus in cell culture. Their drug screen evaluated five other drugs that were not effective. The authors could not be reached for comment. Though the paper is brief, John Lednicky, a professor at the University of Florida’s Emerging Pathogens Institute, found its results intriguing. “It’s interesting in that it really lacks a lot of details but, nevertheless, if you look at the data as presented, at least in vitro, it seems like chloroquine can be used as an early-stage drug,” he said. “It would be very good if these types of experiments were repeated by more laboratories to see whether the same results occur across the board.” Chloroquine is a synthetic form of quinine, a compound found in the bark of cinchona trees native to Peru and used for centuries to treat malaria. Chloroquine was an essential element of mass drug administration campaigns to combat malaria throughout the second half of the 20th century, and remains one of the World Health Organization’s essential medicines. However, after the malaria parasites Plasmodium falciparum and Plasmodium vivax began exhibiting resistance to the drug in the 1960s and 1980s, respectively, it was replaced by similar antimalarial compounds and combination therapies. Chloroquine is still widely used against the three other species of plasmodium and to treat autoimmune disorders and some cases of amebiasis, an intestinal infection caused by the amoeba Entamoeba histolytica. Chloroquine’s antiviral properties were explored in the mid-1990s against HIV and in the following decade against severe acute respiratory syndrome, or SARS, which is closely related to the novel coronavirus. In 2004, researchers in Belgium found that chloroquine inhibited replication of SARS in cell culture. The following year, however, another team at Utah State University and the Chinese University of Hong Kong evaluated a gamut of compounds against SARS replication in mice infected with the virus, finding that chloroquine was only effective as an anti-inflammatory agent. They recommended that it could be used in combination with compounds that prevent replication. Nevertheless, in 2009, the Belgian group found that lethal infections of human coronavirus OC43, a relative of SARS, could be averted in newborn mice by administering chloroquine through the mother’s milk. [end of partial quote] Also: https://www.nature.com/articles/s41422-020-0282-0 Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Manli Wang, Ruiyuan Cao, Leike Zhang, Xinglou Yang, Jia Liu, Mingyue Xu, Zhengli Shi, Zhihong Hu, Wu Zhong & Gengfu Xiao Cell Research (2020)Cite this article 171k Accesses 1108 Altmetric Metrics details Dear Editor, In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million people in central China. The initial cases were linked to exposures in a seafood market in Wuhan.1 As of January 27, 2020, the Chinese authorities reported 2835 confirmed cases in mainland China, including 81 deaths. Additionally, 19 confirmed cases were identified in Hong Kong, Macao and Taiwan, and 39 imported cases were identified in Thailand, Japan, South Korea, United States, Vietnam, Singapore, Nepal, France, Australia and Canada. The pathogen was soon identified as a novel coronavirus (2019-nCoV), which is closely related to sever acute respiratory syndrome CoV (SARS-CoV).2 Currently, there is no specific treatment against the new virus. Therefore, identifying effective antiviral agents to combat the disease is urgently needed. An efficient approach to drug discovery is to test whether the existing antiviral drugs are effective in treating related viral infections. The 2019-nCoV belongs to Betacoronavirus which also contains SARS-CoV and Middle East respiratory syndrome CoV (MERS-CoV). Several drugs, such as ribavirin, interferon, lopinavir-ritonavir, corticosteroids, have been used in patients with SARS or MERS, although the efficacy of some drugs remains controversial.3 In this study, we evaluated the antiviral efficiency of five FAD-approved drugs including ribavirin, penciclovir, nitazoxanide, nafamostat, chloroquine and two well-known broad-spectrum antiviral drugs remdesivir (GS-5734) and favipiravir (T-705) against a clinical isolate of 2019-nCoV in vitro. Standard assays were carried out to measure the effects of these compounds on the cytotoxicity, virus yield and infection rates of 2019-nCoVs. Firstly, the cytotoxicity of the candidate compounds in Vero E6 cells (ATCC-1586) was determined by the CCK8 assay. Then, Vero E6 cells were infected with nCoV-2019BetaCoV/Wuhan/WIV04/20192 at a multiplicity of infection (MOI) of 0.05 in the presence of varying concentrations of the test drugs. DMSO was used in the controls. Efficacies were evaluated by quantification of viral copy numbers in the cell supernatant via quantitative real-time RT-PCR (qRT-PCR) and confirmed with visualization of virus nucleoprotein (NP) expression through immunofluorescence microscopy at 48 h post infection (p.i.) (cytopathic effect was not obvious at this time point of infection). Among the seven tested drugs, high concentrations of three nucleoside analogs including ribavirin (half-maximal effective concentration (EC50) = 109.50 μM, half-cytotoxic concentration (CC50) > 400 μM, selectivity index (SI) > 3.65), penciclovir (EC50 = 95.96 μM, CC50 > 400 μM, SI > 4.17) and favipiravir (EC50 = 61.88 μM, CC50 > 400 μM, SI > 6.46) were required to reduce the viral infection (Fig. 1a and Supplementary information, Fig. S1). However, favipiravir has been shown to be 100% effective in protecting mice against Ebola virus challenge, although its EC50 value in Vero E6 cells was as high as 67 μM,4 suggesting further in vivo studies are recommended to evaluate this antiviral nucleoside. Nafamostat, a potent inhibitor of MERS-CoV, which prevents membrane fusion, was inhibitive against the 2019-nCoV infection (EC50 = 22.50 μM, CC50 > 100 μM, SI > 4.44). Nitazoxanide, a commercial antiprotozoal agent with an antiviral potential against a broad range of viruses including human and animal coronaviruses, inhibited the 2019-nCoV at a low-micromolar concentration (EC50 = 2.12 μM; CC50 > 35.53 μM; SI > 16.76). Further in vivo evaluation of this drug against 2019-nCoV infection is recommended. Notably, two compounds remdesivir (EC50 = 0.77 μM; CC50 > 100 μM; SI > 129.87) and chloroquine (EC50 = 1.13 μM; CC50 > 100 μM, SI > 88.50) potently blocked virus infection at low-micromolar concentration and showed high SI (Fig. 1a, b). | | | | | | | | | | | Anti-parasitic drug kills coronavirus cell cultures in just 48 hours "If we had a compound that was already available around the world then that might help people sooner." | | |

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