May 2020 - cypherpunks - lists.cpunks.org

Chloroquine is "highly effective" at inhibiting reproduction of Novel Coronavirus nCov in cell culture.
by jim bell 20 Dec '20

20 Dec '20

https://www.dailymail.co.uk/health/article-8184997/Doctors-worldwide-say-ma… Doctors around the globe report that the malaria drug hydroxychloroquine seems the most effective treatment they've tried for coronavirus patients - but less than half as many doctors are prescribing it in the US as in other hard-hit countries like Spain. A survey of 6,200 doctors around the globe reveals that while few corners of the world are untouched by the virus, the pandemic is being handled very differently from country-to-country. And in some measures, the US continues to fall behind other nations' responses. For example, an American waits an average of four to five days to get results back after being tested for COVID-19. Half of doctors in Europe and most in China get the test results back within 24-hours. Dr Murali Doraiswamy, an adviser to Sermo, urged that countries should take note of what is working for doctors and governments elsewhere and move quickly to adopt practices that are saving lives. Hydroxychloroquine (pictured) was deemed the most effective coronavirus treatment comared to other options by more doctors worldwide than any other in a global survey =========================================================== On Sat, Feb 8, 2020 at 9:18 PM jim bell <jdb10987(a)yahoo.com> wrote: jim bell [chloroquine is an old-line drug typically used against malaria] [partial quote follows] https://www.asbmb.org/asbmb-today/science/020620/could-an-old-malaria-drug-… ASBMB Today Science Could an old malaria drug help fight the new coronavirus? Could an old malaria drug help fight the new coronavirus? By John Arnst February 06, 2020 Chloroquine might be getting new life as an antiviral treatment for the novel coronavirus that emerged in Wuhan, China in late 2019 and has infected some 25,000 people in more than 25 countries. For decades, the drug was a front-line treatment and prophylactic for malaria. In a three-page paper published Tuesday in Cell Research, scientists at the Wuhan Institute of Virology’s State Key Laboratory of Virology write that both chloroquine and the antiviral remdesivir were, individually, “highly effective” at inhibiting replication of the novel coronavirus in cell culture. Their drug screen evaluated five other drugs that were not effective. The authors could not be reached for comment. Though the paper is brief, John Lednicky, a professor at the University of Florida’s Emerging Pathogens Institute, found its results intriguing. “It’s interesting in that it really lacks a lot of details but, nevertheless, if you look at the data as presented, at least in vitro, it seems like chloroquine can be used as an early-stage drug,” he said. “It would be very good if these types of experiments were repeated by more laboratories to see whether the same results occur across the board.” Chloroquine is a synthetic form of quinine, a compound found in the bark of cinchona trees native to Peru and used for centuries to treat malaria. Chloroquine was an essential element of mass drug administration campaigns to combat malaria throughout the second half of the 20th century, and remains one of the World Health Organization’s essential medicines. However, after the malaria parasites Plasmodium falciparum and Plasmodium vivax began exhibiting resistance to the drug in the 1960s and 1980s, respectively, it was replaced by similar antimalarial compounds and combination therapies. Chloroquine is still widely used against the three other species of plasmodium and to treat autoimmune disorders and some cases of amebiasis, an intestinal infection caused by the amoeba Entamoeba histolytica. Chloroquine’s antiviral properties were explored in the mid-1990s against HIV and in the following decade against severe acute respiratory syndrome, or SARS, which is closely related to the novel coronavirus. In 2004, researchers in Belgium found that chloroquine inhibited replication of SARS in cell culture. The following year, however, another team at Utah State University and the Chinese University of Hong Kong evaluated a gamut of compounds against SARS replication in mice infected with the virus, finding that chloroquine was only effective as an anti-inflammatory agent. They recommended that it could be used in combination with compounds that prevent replication. Nevertheless, in 2009, the Belgian group found that lethal infections of human coronavirus OC43, a relative of SARS, could be averted in newborn mice by administering chloroquine through the mother’s milk. [end of partial quote] Also: https://www.nature.com/articles/s41422-020-0282-0 Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Manli Wang, Ruiyuan Cao, Leike Zhang, Xinglou Yang, Jia Liu, Mingyue Xu, Zhengli Shi, Zhihong Hu, Wu Zhong & Gengfu Xiao Cell Research (2020)Cite this article 171k Accesses 1108 Altmetric Metrics details Dear Editor, In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million people in central China. The initial cases were linked to exposures in a seafood market in Wuhan.1 As of January 27, 2020, the Chinese authorities reported 2835 confirmed cases in mainland China, including 81 deaths. Additionally, 19 confirmed cases were identified in Hong Kong, Macao and Taiwan, and 39 imported cases were identified in Thailand, Japan, South Korea, United States, Vietnam, Singapore, Nepal, France, Australia and Canada. The pathogen was soon identified as a novel coronavirus (2019-nCoV), which is closely related to sever acute respiratory syndrome CoV (SARS-CoV).2 Currently, there is no specific treatment against the new virus. Therefore, identifying effective antiviral agents to combat the disease is urgently needed. An efficient approach to drug discovery is to test whether the existing antiviral drugs are effective in treating related viral infections. The 2019-nCoV belongs to Betacoronavirus which also contains SARS-CoV and Middle East respiratory syndrome CoV (MERS-CoV). Several drugs, such as ribavirin, interferon, lopinavir-ritonavir, corticosteroids, have been used in patients with SARS or MERS, although the efficacy of some drugs remains controversial.3 In this study, we evaluated the antiviral efficiency of five FAD-approved drugs including ribavirin, penciclovir, nitazoxanide, nafamostat, chloroquine and two well-known broad-spectrum antiviral drugs remdesivir (GS-5734) and favipiravir (T-705) against a clinical isolate of 2019-nCoV in vitro. Standard assays were carried out to measure the effects of these compounds on the cytotoxicity, virus yield and infection rates of 2019-nCoVs. Firstly, the cytotoxicity of the candidate compounds in Vero E6 cells (ATCC-1586) was determined by the CCK8 assay. Then, Vero E6 cells were infected with nCoV-2019BetaCoV/Wuhan/WIV04/20192 at a multiplicity of infection (MOI) of 0.05 in the presence of varying concentrations of the test drugs. DMSO was used in the controls. Efficacies were evaluated by quantification of viral copy numbers in the cell supernatant via quantitative real-time RT-PCR (qRT-PCR) and confirmed with visualization of virus nucleoprotein (NP) expression through immunofluorescence microscopy at 48 h post infection (p.i.) (cytopathic effect was not obvious at this time point of infection). Among the seven tested drugs, high concentrations of three nucleoside analogs including ribavirin (half-maximal effective concentration (EC50) = 109.50 μM, half-cytotoxic concentration (CC50) > 400 μM, selectivity index (SI) > 3.65), penciclovir (EC50 = 95.96 μM, CC50 > 400 μM, SI > 4.17) and favipiravir (EC50 = 61.88 μM, CC50 > 400 μM, SI > 6.46) were required to reduce the viral infection (Fig. 1a and Supplementary information, Fig. S1). However, favipiravir has been shown to be 100% effective in protecting mice against Ebola virus challenge, although its EC50 value in Vero E6 cells was as high as 67 μM,4 suggesting further in vivo studies are recommended to evaluate this antiviral nucleoside. Nafamostat, a potent inhibitor of MERS-CoV, which prevents membrane fusion, was inhibitive against the 2019-nCoV infection (EC50 = 22.50 μM, CC50 > 100 μM, SI > 4.44). Nitazoxanide, a commercial antiprotozoal agent with an antiviral potential against a broad range of viruses including human and animal coronaviruses, inhibited the 2019-nCoV at a low-micromolar concentration (EC50 = 2.12 μM; CC50 > 35.53 μM; SI > 16.76). Further in vivo evaluation of this drug against 2019-nCoV infection is recommended. Notably, two compounds remdesivir (EC50 = 0.77 μM; CC50 > 100 μM; SI > 129.87) and chloroquine (EC50 = 1.13 μM; CC50 > 100 μM, SI > 88.50) potently blocked virus infection at low-micromolar concentration and showed high SI (Fig. 1a, b).

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Moar Woar Poarn - Fw: Raqqa drift! Oh yeah :D
by Zig the N.g 17 Dec '20

17 Dec '20

Gets a little crazy on the roads o' Raqqa, muh stucco muffas :) How it truly went down: US0: "These fuckin' Syrians put a fuckin' country round our oil field - how DARE they!" US1: "Yeah, fuckin' sand niggers!" [Russkie's literally start to approach on highway, from behind.] RU0: "Ho, boys! Amerikanski oil "protectors" ahead. What do we?" RU1: "Ohoh! Drift this Tigr, baby - We's Baaaack!!" [serious literal military vehicle fast and furious ensues - see links below] [Russkies take first hummer, start hunting down second...] US0: "Muthufuckas! We got Russkies, lads, hang on tight!" [US2-4 happy they remembered "low frequency protection unit" adult diapers this morning.] RU0: "YEEEEE HAAAAAAW FIRETRUCKERRRRRRRRRRRRRRRRRRS!!!!" US1: [death gripping handle bar] "Oahhhh shiiiiit - why you driving offroaoad, buddy?!#!" US0: "Don't be a fuckin nigger! I think she'll make it - roadside don't look too fuckin rough." RU1: [grinning madly out side window at US hummer boys] "Baby, yeah! Lose you we will!" [to Ru0:] "SHIT! Watch locals, brutha!" [Russians narrowly miss a local who jumps out of the way] RU0: "May be lose them, but anuddah Oil thief pass we must!" RU1: "NO breaks, brutha! Do your copyright 'Boris Oil Thief Wedgy' manouver! Baby, yeah!" RU0: "Got it, brutha!" [hits accelerator hard, wedges all 3 vehicles as they come to screaming halt] [poetic license, not quite what actually happened, but part of upcoming movie script] US0: "HEY MUTHAFUCKAS WHAT THE FUCKIN FUCK ARE YA DOING!" US1: "FUUUUUUUUUUUUCK - Fucking PAPERWORK! FUCK YOU RUSSKIE!!" RU0: [cracks a 4L vodka bottle] "Here, drink have you, brutha!" RU1: [with huge cat eatin grin] "Awww, done cry little oil thief! Vodka take your paperwork away - HA HA HAAAA!" US0+1: "FUCK!!!" [See second 'tube below for Syrian villagers warmly welcoming American "democracy bringers" - with multiple gun shots :D] ----- Forwarded message from Zenaan Harkness <zen(a)freedbms.net> ----- Date: Thu, 20 Feb 2020 11:12:28 +1100 Subject: Raqqa drift! Oh yeah :D Enjoy ;) https://www.zerohedge.com/geopolitical/bizarre-road-rage-among-superpowers-… ----- End forwarded message -----

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[OT] [song] Patti Smith - People Have The Power
by Cecilia Tanaka 13 Dec '20

13 Dec '20

https://youtu.be/pPR-HyGj2d0 Patti Smith - People Have The Power I was dreaming in my dreaming Of an aspect bright and fair And my sleeping it was broken But my dream it lingered near In the form of shining valleys Where the pure air recognized And my senses newly opened I awakened to the cry That the people / have the power To redeem / the work of fools Upon the meek / the graces shower It's decreed / the people rule The people have the power The people have the power The people have the power The people have the power Vengeful aspects became suspect And bending low as if to hear And the armies ceased advancing Because the people had their ear And the shepherds and the soldiers Lay beneath the stars Exchanging visions And laying arms To waste / in the dust In the form of / shining valleys Where the pure air / recognized And my senses / newly opened I awakened / to the cry Refrain Where there were deserts I saw fountains Like cream the waters rise And we strolled there together With none to laugh or criticize And the leopard And the lamb Lay together truly bound I was hoping in my hoping To recall what I had found I was dreaming in my dreaming God knows / a purer view As I surrender to my sleeping I commit my dream to you Refrain The power to dream / to rule To wrestle the world from fools It's decreed the people rule It's decreed the people rule LISTEN I believe everything we dream Can come to pass through our union We can turn the world around We can turn the earth's revolution We have the power People have the power ...

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Julian Assange to be pardoned by Trump?
by CANNON 13 Dec '20

13 Dec '20

Rumor has it Trump is planning on pardoning Julian Assange, founder of whistleblower website Wikileaks.

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Kim Dotcom on Seth Rich's USB; USA: Whites not hate-filled enough for Dem program to succeed - [PEACE]
by Zenaan Harkness 10 Dec '20

10 Dec '20

** BREAKING: Kim Dotcom Tweets at Hannity: ‘Let's Talk About Seth Rich ... And Put an End to Russiagate’ https://russia-insider.us9.list-manage.com/track/click?u=fa2faf7034c3c3c413… ------------------------------------------------------------ by Michael Quinn Sat, Jan 26, 2019 Kim Dotcom, the infamous entrepreneur and political activist, wants to put an end to Russiagate. He has been talking about Wikileaks and Clinton since May 2015, which was a month before Donald Trump even announced his presidential campaign: Kim Dotcom: Julian Assange Will Be Hillary Clinton’s Worst Nightmare in 2016 ** Identity Stalinism: The Left's Incoherence Will Be Its Undoing https://russia-insider.us9.list-manage.com/track/click?u=fa2faf7034c3c3c413… ------------------------------------------------------------ by Steve Sailer Taki's Magazine Sat, Jan 26, 2019 The media’s latest Days of Rage, in which a white boy drove the national press into a frenzy by smiling at the leftist Person of Color banging a drum in his face, was like a greatest-hits collection of my old observations. So I’m going to take a victory lap to review how ideas I’ve been offering for years help explain much of the latest elite fury.

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Coronavirus Tech Handbook
by Hannah O'Rourke 10 Dec '20

10 Dec '20

Hi all! Hope you’re all safe and isolated - I found this, seems to be the best resource for organising efforts around Coronavirus: https://coronavirustechhandbook.com/home All the data and graphs you could ever want, tips for remote working, tools for organising mutual aid groups, and crowdsourced specialist advice for doctors, teachers, charities, all kinds of things. Have a look.

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Area51: S4 UFO AATIP Nimitz Fravor Lazar TTSA Physics Alien Tech
by grarpamp 08 Dec '20

08 Dec '20

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[MINISTRY] [FREE SPEECH] [QUESTIONING (((THE NARRATIVE)))] grandma Haverbeck caught, 2 yrs jail
by Zenaan Harkness 06 Dec '20

06 Dec '20

Grandma Haverbeck, who has for 70 odd years been humbly asking for evidence of the hallowed holy gas chambers (like, for example, something OTHER than the rickety wooden pailing-fence gates as the supposed doors of the Auschwitz gas chambers, or any other non refutable evidence for that matter...) went on the lam and the German "authorities" finally caught up with her. 2 years jail begins. https://dailystormer.name/germany-jews-catch-evil-nazi-grandma-who-asked-fo… Germany: Jews Catch Evil Nazi Grandma Who Asked for Evidence of Gas Chambers By the way, the Germans, prior to WW2, did in fact make gas chambers, and made them very firetrucking well thank very firetrucking much - reinforced, hermetically sealed stainless steel "submarine equivalent" doors thank you very much - a far cry from rickety wooden pailing fence gates masquerading as "gas chamber" doors. Good luck Ursula Haverbeck, may God and righteousness be with you. The sane world,

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Ukraine: MH17 "escorted" by military jet just prior to BUK missile shoot down - [PEACE]
by Zenaan Harkness 06 Dec '20

06 Dec '20

So the Deep State fake news apparatus rumbles on whilst occasionally putting out a few facts which are so "problematic" they are immediately censored - in this case the BBC exposed an interview of two Ukrainian citizens who witnessed MH17 being "escorted" by a military jet just prior to MH17 being blown out of the sky, apparently by a BUK missile which had been in exclusive Ukrainian possession since a day after in left it's Soviet factory in 1986. Zerowedgie fills us in with an execessively wordy, yet sadly comical highlights from the 'Joint Investigative Team's own reports - ultimately unequivocally indicting Ukraine, the Netherlands, Belgium and also Australia dang it. Bemoaning the degradation of the West. So sad. MH17 Turnabout: Ukraine's Guilt Now Proven https://www.zerohedge.com/news/2019-01-01/mh17-turnabout-ukraines-guilt-now…

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A just outcome -- [change@e.change.org: Amber Heard has been fired from Aquaman 2]
by Zig the N.g 05 Dec '20

05 Dec '20

Ooh, yeah, I heard it through the grape vine. ;) ----- Forwarded message from "Jeanne Larson via Change.org" <change(a)e.change.org> ----- From: "Jeanne Larson via Change.org" <change(a)e.change.org> Reply-To: "Change.org" <reply.en-AU(a)reply.e.change.org> Date: Fri, 08 May 2020 19:23:45 +0000 Subject: Amber Heard has been fired from Aquaman 2 List-Id: <spc.222165.2.sparkpostmail.com> Jeanne Larson shared an update on <em>Remove Amber Heard from Aquaman 2</em> Check it out and leave a comment: Petition Update Amber Heard has been fired from Aquaman 2 Some inside sources have unofficially confirmed that Amber Heard has been sacked from AM2. Apparently they don't want to start filming and then get left in the lurch if she gets hauled off to jail for falsifying evidence, a very real possibility. It's not official confirmation, but it's the next best thing. It's likely that the official announcement will come after Johnny Depp wins one or both... https://click.e.change.org/f/a/wWc9VSnHzZgVbj_sknzOxA~~/AANj1QA~/RgRgmDbBP4… Discover petitions promoted by Change.org users Bring Priya and her beautiful family back home to Biloela, Queensland Show you care about our Aussie Farmers in Drought... Provide Adequate and Practical Respiratory Protection for... Crown to appeal the sentance of the girl that killed our son in a hit... Australian Healthcare Workers demand safe Personal Protective... ----- End forwarded message -----

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