November 2020 - cypherpunks - lists.cpunks.org

Chloroquine is "highly effective" at inhibiting reproduction of Novel Coronavirus nCov in cell culture.
by jim bell 20 Dec '20

20 Dec '20

https://www.dailymail.co.uk/health/article-8184997/Doctors-worldwide-say-ma… Doctors around the globe report that the malaria drug hydroxychloroquine seems the most effective treatment they've tried for coronavirus patients - but less than half as many doctors are prescribing it in the US as in other hard-hit countries like Spain. A survey of 6,200 doctors around the globe reveals that while few corners of the world are untouched by the virus, the pandemic is being handled very differently from country-to-country. And in some measures, the US continues to fall behind other nations' responses. For example, an American waits an average of four to five days to get results back after being tested for COVID-19. Half of doctors in Europe and most in China get the test results back within 24-hours. Dr Murali Doraiswamy, an adviser to Sermo, urged that countries should take note of what is working for doctors and governments elsewhere and move quickly to adopt practices that are saving lives. Hydroxychloroquine (pictured) was deemed the most effective coronavirus treatment comared to other options by more doctors worldwide than any other in a global survey =========================================================== On Sat, Feb 8, 2020 at 9:18 PM jim bell <jdb10987(a)yahoo.com> wrote: jim bell [chloroquine is an old-line drug typically used against malaria] [partial quote follows] https://www.asbmb.org/asbmb-today/science/020620/could-an-old-malaria-drug-… ASBMB Today Science Could an old malaria drug help fight the new coronavirus? Could an old malaria drug help fight the new coronavirus? By John Arnst February 06, 2020 Chloroquine might be getting new life as an antiviral treatment for the novel coronavirus that emerged in Wuhan, China in late 2019 and has infected some 25,000 people in more than 25 countries. For decades, the drug was a front-line treatment and prophylactic for malaria. In a three-page paper published Tuesday in Cell Research, scientists at the Wuhan Institute of Virology’s State Key Laboratory of Virology write that both chloroquine and the antiviral remdesivir were, individually, “highly effective” at inhibiting replication of the novel coronavirus in cell culture. Their drug screen evaluated five other drugs that were not effective. The authors could not be reached for comment. Though the paper is brief, John Lednicky, a professor at the University of Florida’s Emerging Pathogens Institute, found its results intriguing. “It’s interesting in that it really lacks a lot of details but, nevertheless, if you look at the data as presented, at least in vitro, it seems like chloroquine can be used as an early-stage drug,” he said. “It would be very good if these types of experiments were repeated by more laboratories to see whether the same results occur across the board.” Chloroquine is a synthetic form of quinine, a compound found in the bark of cinchona trees native to Peru and used for centuries to treat malaria. Chloroquine was an essential element of mass drug administration campaigns to combat malaria throughout the second half of the 20th century, and remains one of the World Health Organization’s essential medicines. However, after the malaria parasites Plasmodium falciparum and Plasmodium vivax began exhibiting resistance to the drug in the 1960s and 1980s, respectively, it was replaced by similar antimalarial compounds and combination therapies. Chloroquine is still widely used against the three other species of plasmodium and to treat autoimmune disorders and some cases of amebiasis, an intestinal infection caused by the amoeba Entamoeba histolytica. Chloroquine’s antiviral properties were explored in the mid-1990s against HIV and in the following decade against severe acute respiratory syndrome, or SARS, which is closely related to the novel coronavirus. In 2004, researchers in Belgium found that chloroquine inhibited replication of SARS in cell culture. The following year, however, another team at Utah State University and the Chinese University of Hong Kong evaluated a gamut of compounds against SARS replication in mice infected with the virus, finding that chloroquine was only effective as an anti-inflammatory agent. They recommended that it could be used in combination with compounds that prevent replication. Nevertheless, in 2009, the Belgian group found that lethal infections of human coronavirus OC43, a relative of SARS, could be averted in newborn mice by administering chloroquine through the mother’s milk. [end of partial quote] Also: https://www.nature.com/articles/s41422-020-0282-0 Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Manli Wang, Ruiyuan Cao, Leike Zhang, Xinglou Yang, Jia Liu, Mingyue Xu, Zhengli Shi, Zhihong Hu, Wu Zhong & Gengfu Xiao Cell Research (2020)Cite this article 171k Accesses 1108 Altmetric Metrics details Dear Editor, In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million people in central China. The initial cases were linked to exposures in a seafood market in Wuhan.1 As of January 27, 2020, the Chinese authorities reported 2835 confirmed cases in mainland China, including 81 deaths. Additionally, 19 confirmed cases were identified in Hong Kong, Macao and Taiwan, and 39 imported cases were identified in Thailand, Japan, South Korea, United States, Vietnam, Singapore, Nepal, France, Australia and Canada. The pathogen was soon identified as a novel coronavirus (2019-nCoV), which is closely related to sever acute respiratory syndrome CoV (SARS-CoV).2 Currently, there is no specific treatment against the new virus. Therefore, identifying effective antiviral agents to combat the disease is urgently needed. An efficient approach to drug discovery is to test whether the existing antiviral drugs are effective in treating related viral infections. The 2019-nCoV belongs to Betacoronavirus which also contains SARS-CoV and Middle East respiratory syndrome CoV (MERS-CoV). Several drugs, such as ribavirin, interferon, lopinavir-ritonavir, corticosteroids, have been used in patients with SARS or MERS, although the efficacy of some drugs remains controversial.3 In this study, we evaluated the antiviral efficiency of five FAD-approved drugs including ribavirin, penciclovir, nitazoxanide, nafamostat, chloroquine and two well-known broad-spectrum antiviral drugs remdesivir (GS-5734) and favipiravir (T-705) against a clinical isolate of 2019-nCoV in vitro. Standard assays were carried out to measure the effects of these compounds on the cytotoxicity, virus yield and infection rates of 2019-nCoVs. Firstly, the cytotoxicity of the candidate compounds in Vero E6 cells (ATCC-1586) was determined by the CCK8 assay. Then, Vero E6 cells were infected with nCoV-2019BetaCoV/Wuhan/WIV04/20192 at a multiplicity of infection (MOI) of 0.05 in the presence of varying concentrations of the test drugs. DMSO was used in the controls. Efficacies were evaluated by quantification of viral copy numbers in the cell supernatant via quantitative real-time RT-PCR (qRT-PCR) and confirmed with visualization of virus nucleoprotein (NP) expression through immunofluorescence microscopy at 48 h post infection (p.i.) (cytopathic effect was not obvious at this time point of infection). Among the seven tested drugs, high concentrations of three nucleoside analogs including ribavirin (half-maximal effective concentration (EC50) = 109.50 μM, half-cytotoxic concentration (CC50) > 400 μM, selectivity index (SI) > 3.65), penciclovir (EC50 = 95.96 μM, CC50 > 400 μM, SI > 4.17) and favipiravir (EC50 = 61.88 μM, CC50 > 400 μM, SI > 6.46) were required to reduce the viral infection (Fig. 1a and Supplementary information, Fig. S1). However, favipiravir has been shown to be 100% effective in protecting mice against Ebola virus challenge, although its EC50 value in Vero E6 cells was as high as 67 μM,4 suggesting further in vivo studies are recommended to evaluate this antiviral nucleoside. Nafamostat, a potent inhibitor of MERS-CoV, which prevents membrane fusion, was inhibitive against the 2019-nCoV infection (EC50 = 22.50 μM, CC50 > 100 μM, SI > 4.44). Nitazoxanide, a commercial antiprotozoal agent with an antiviral potential against a broad range of viruses including human and animal coronaviruses, inhibited the 2019-nCoV at a low-micromolar concentration (EC50 = 2.12 μM; CC50 > 35.53 μM; SI > 16.76). Further in vivo evaluation of this drug against 2019-nCoV infection is recommended. Notably, two compounds remdesivir (EC50 = 0.77 μM; CC50 > 100 μM; SI > 129.87) and chloroquine (EC50 = 1.13 μM; CC50 > 100 μM, SI > 88.50) potently blocked virus infection at low-micromolar concentration and showed high SI (Fig. 1a, b).

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FreeSpeech: Parler CEO re BigSoc Censors - It's Not Against The Law To Have Those Opinions
by grarpamp 19 Dec '20

19 Dec '20

https://www.theepochtimes.com/parler-ceo-defends-free-speech-its-not-agains… https://video.foxnews.com/v/6210514362001 The CEO of Parler, which has been described as an alternative to Twitter, defended free speech in an interview on Tuesday in the midst of mainstream media-led criticism of the social media platform. “People say crazy things all the time,” and “it’s not against the law to have those opinions,” Parler CEO John Matze told Fox News. He was responding to a question about why establishment media outlets have taken an increasingly critical tone against the platform. “I always ask them, ‘What do you think of the First Amendment? Do you believe that we should have somebody in New York, let’s say in the middle of Times Square, telling you what you can and cannot say?’” Matze said. “Because that’s what these companies are doing.” “I don’t know why they’re so afraid. Maybe it’s because they don’t like that people are getting power again,” he continued. “But it’s not against the law to have those opinions,” Matze added. “It’s not against the law to express yourself. And if you like one political candidate or another, or you believe or don’t believe in climate change,” he continued, “you shouldn’t be taken offline because of it.” After the Nov. 3 elections, Parler has seen a boost in users and traffic, coming after some conservative pundits and officials moved to the platform from Twitter. The firm in late September posted a message about Election Day, saying it will be “a hub for unfettered, curation-free information before, during, and after the November 3 election.” The firm then took a shot at Facebook, Google, and Twitter for attempting to control the flow of information. “Google, Facebook, and Twitter, by contrast, have announced plans to control the dissemination of ‘misinformation,’ which means, in effect: to take it upon themselves to tell their users what information they should trust and, ultimately, what they should think,” it said. The three firms have posted disclaimers, fact checks, and have limited the reach on posts that allegedly run afoul of narratives they seek to promote. Matze’s comments come as Twitter CEO Jack Dorsey and Facebook CEO Mark Zuckerberg came under fire from Senate Republicans in a Judiciary Committee hearing on Tuesday. “That to me seems like you’re the ultimate editor,” committee chairman Sen. Lindsey Graham (R-S.C.) said during his opening statement to the two CEOs. “The editorial decision by the New York Post to run the story was overridden by Twitter and Facebook in different fashions to prevent its dissemination. Now if that’s not making an editorial decision I don’t know what would be.” Some media pundits as well as researchers have complained that Parler allows for the spread of so-called conspiracy theories or disinformation. Bret Schafer, a fellow focusing on disinformation at the Alliance for Securing Democracy, told The Hill: “Anytime you take a laissez-faire approach to moderation —you say ‘anything goes’ right up until actual threats of real world violence—that creates a huge space for some really problematic things to happen.” He didn’t provide any evidence that showed whether views expressed on Parler have led to violence.

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Moar Woar Poarn - Fw: Raqqa drift! Oh yeah :D
by Zig the N.g 17 Dec '20

17 Dec '20

Gets a little crazy on the roads o' Raqqa, muh stucco muffas :) How it truly went down: US0: "These fuckin' Syrians put a fuckin' country round our oil field - how DARE they!" US1: "Yeah, fuckin' sand niggers!" [Russkie's literally start to approach on highway, from behind.] RU0: "Ho, boys! Amerikanski oil "protectors" ahead. What do we?" RU1: "Ohoh! Drift this Tigr, baby - We's Baaaack!!" [serious literal military vehicle fast and furious ensues - see links below] [Russkies take first hummer, start hunting down second...] US0: "Muthufuckas! We got Russkies, lads, hang on tight!" [US2-4 happy they remembered "low frequency protection unit" adult diapers this morning.] RU0: "YEEEEE HAAAAAAW FIRETRUCKERRRRRRRRRRRRRRRRRRS!!!!" US1: [death gripping handle bar] "Oahhhh shiiiiit - why you driving offroaoad, buddy?!#!" US0: "Don't be a fuckin nigger! I think she'll make it - roadside don't look too fuckin rough." RU1: [grinning madly out side window at US hummer boys] "Baby, yeah! Lose you we will!" [to Ru0:] "SHIT! Watch locals, brutha!" [Russians narrowly miss a local who jumps out of the way] RU0: "May be lose them, but anuddah Oil thief pass we must!" RU1: "NO breaks, brutha! Do your copyright 'Boris Oil Thief Wedgy' manouver! Baby, yeah!" RU0: "Got it, brutha!" [hits accelerator hard, wedges all 3 vehicles as they come to screaming halt] [poetic license, not quite what actually happened, but part of upcoming movie script] US0: "HEY MUTHAFUCKAS WHAT THE FUCKIN FUCK ARE YA DOING!" US1: "FUUUUUUUUUUUUCK - Fucking PAPERWORK! FUCK YOU RUSSKIE!!" RU0: [cracks a 4L vodka bottle] "Here, drink have you, brutha!" RU1: [with huge cat eatin grin] "Awww, done cry little oil thief! Vodka take your paperwork away - HA HA HAAAA!" US0+1: "FUCK!!!" [See second 'tube below for Syrian villagers warmly welcoming American "democracy bringers" - with multiple gun shots :D] ----- Forwarded message from Zenaan Harkness <zen(a)freedbms.net> ----- Date: Thu, 20 Feb 2020 11:12:28 +1100 Subject: Raqqa drift! Oh yeah :D Enjoy ;) https://www.zerohedge.com/geopolitical/bizarre-road-rage-among-superpowers-… ----- End forwarded message -----

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[OT] [song] Patti Smith - People Have The Power
by Cecilia Tanaka 13 Dec '20

13 Dec '20

https://youtu.be/pPR-HyGj2d0 Patti Smith - People Have The Power I was dreaming in my dreaming Of an aspect bright and fair And my sleeping it was broken But my dream it lingered near In the form of shining valleys Where the pure air recognized And my senses newly opened I awakened to the cry That the people / have the power To redeem / the work of fools Upon the meek / the graces shower It's decreed / the people rule The people have the power The people have the power The people have the power The people have the power Vengeful aspects became suspect And bending low as if to hear And the armies ceased advancing Because the people had their ear And the shepherds and the soldiers Lay beneath the stars Exchanging visions And laying arms To waste / in the dust In the form of / shining valleys Where the pure air / recognized And my senses / newly opened I awakened / to the cry Refrain Where there were deserts I saw fountains Like cream the waters rise And we strolled there together With none to laugh or criticize And the leopard And the lamb Lay together truly bound I was hoping in my hoping To recall what I had found I was dreaming in my dreaming God knows / a purer view As I surrender to my sleeping I commit my dream to you Refrain The power to dream / to rule To wrestle the world from fools It's decreed the people rule It's decreed the people rule LISTEN I believe everything we dream Can come to pass through our union We can turn the world around We can turn the earth's revolution We have the power People have the power ...

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Julian Assange to be pardoned by Trump?
by CANNON 13 Dec '20

13 Dec '20

Rumor has it Trump is planning on pardoning Julian Assange, founder of whistleblower website Wikileaks.

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Kim Dotcom on Seth Rich's USB; USA: Whites not hate-filled enough for Dem program to succeed - [PEACE]
by Zenaan Harkness 10 Dec '20

10 Dec '20

** BREAKING: Kim Dotcom Tweets at Hannity: ‘Let's Talk About Seth Rich ... And Put an End to Russiagate’ https://russia-insider.us9.list-manage.com/track/click?u=fa2faf7034c3c3c413… ------------------------------------------------------------ by Michael Quinn Sat, Jan 26, 2019 Kim Dotcom, the infamous entrepreneur and political activist, wants to put an end to Russiagate. He has been talking about Wikileaks and Clinton since May 2015, which was a month before Donald Trump even announced his presidential campaign: Kim Dotcom: Julian Assange Will Be Hillary Clinton’s Worst Nightmare in 2016 ** Identity Stalinism: The Left's Incoherence Will Be Its Undoing https://russia-insider.us9.list-manage.com/track/click?u=fa2faf7034c3c3c413… ------------------------------------------------------------ by Steve Sailer Taki's Magazine Sat, Jan 26, 2019 The media’s latest Days of Rage, in which a white boy drove the national press into a frenzy by smiling at the leftist Person of Color banging a drum in his face, was like a greatest-hits collection of my old observations. So I’m going to take a victory lap to review how ideas I’ve been offering for years help explain much of the latest elite fury.

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Coronavirus Tech Handbook
by Hannah O'Rourke 10 Dec '20

10 Dec '20

Hi all! Hope you’re all safe and isolated - I found this, seems to be the best resource for organising efforts around Coronavirus: https://coronavirustechhandbook.com/home All the data and graphs you could ever want, tips for remote working, tools for organising mutual aid groups, and crowdsourced specialist advice for doctors, teachers, charities, all kinds of things. Have a look.

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Area51: S4 UFO AATIP Nimitz Fravor Lazar TTSA Physics Alien Tech
by grarpamp 08 Dec '20

08 Dec '20

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The fight is on, and not for the first time - FDR, JFK - Gen. Butlers, where are you? - [PEACE] [HISTORY REPEATS]
by Zenaan Harkness 08 Dec '20

08 Dec '20

History might in some ways repeat, but hopefully this time there shall be a difference. Create your world, Trump Vs The Military-Industrial-Complex: Coup Concerns Escalate Matthew Ehret via The Saker blog http://thesaker.is/trump-vs-the-military-industrial-complex-military-coup-d… https://www.zerohedge.com/geopolitical/trump-vs-military-industrial-complex… At last week’s Labor Day conference, President Trump threw down the gauntlet in opposition to the Anglo American military industrial complex when both inspired hope in many onlookers that the age of America’s “endless wars” might finally come to an end, but also fear that an emergence Military Coup danger was nigh. This danger was enunciated by State Senator Richard Black (a former Colonel and intelligence officer) during a September 5 conference. In his powerful speech which won the ire of top Pentagon brass, Trump called for finally bringing America’s troops home, and ending the “endless wars” saying: “I’m not saying the military is in love with me; the soldiers are. The top people in the Pentagon probably aren’t, because they want to do nothing but fight wars so that all of those wonderful companies that make the bombs, and make the planes, and make everything else, stay happy. But we’re getting out of the endless wars…. Let’s bring our soldiers back home.” For those devout Trump haters who are unwilling to accept the possibility that there has been an active coup run against the President for the past 3.5 years, or that the oncoming economic meltdown (unleashed under the cover of COVID-19) and general civil war danger within the USA might usher in a coup d’etat… think again. ... The Fascist Economic Miracle Solution of 1932 ... The Rise of Franklin Roosevelt ... During FDR’s famous 100 Days, an all-out war was declared on the “economic royalists” that had taken over the nation. Audits and investigations were conducted on the banks in the form of the Pecora Commission, and the biggest financial houses which had spent billions on fascist parties of Europe were broken up while speculation was reined in under Glass-Steagall. Meanwhile a new form of banking was unveiled more in alignment with America’s constitutional traditions in the form of productive credit and long term public works which created real jobs and increased the national productive powers of labor. Many people remain totally ignorant that even before his March 4, 1933 inauguration, Franklin Roosevelt narrowly avoided an assassination attempt in Florida which saw 5 people struck by bullets and the mayor of Chicago dying of his wounds 3 weeks later. Within days of the mayor’s death, the assassin Giuseppe Zingara was speedily labelled a “lone gunman” and executed without any serious investigation into his freemasonic connections. This however was just a pre-cursor for an even greater battle which Wall Street financiers would launch in order to overthrow the presidency later that year. This effort would only be stopped by the courageous intervention of a patriotic marine named Smedley Darlington Butler. ... Who was General Butler? ... The Wall Street Putsch is Launched ... Butler Blows the Whistle ... Although the full transcripts were not made public, Butler did get the message to the population by giving his story to as many journalists as possible and recorded a message to the people in 1935 which should be listened to in full. http://www.youtube.com/watch?v=djHA2-TAbrQ The Aftermath of the Exposure This exposure, alongside the Pecora Commission findings, and earlier failed assassination attempt gave FDR the ammunition he needed to force America’s deep state into submission (at least for a while). As I outlined in my recent paper, FDR’s fight to stop a central bankers’ dictatorship started from the earliest days of his presidency to his dying breath on April 14, 1945. https://www.strategic-culture.org/news/2020/03/16/standing-at-precipice-of-… https://www.strategic-culture.org/news/2019/11/08/how-to-crush-bankers-dict… Incredibly, after the sanitized and redacted 1934 report was published, the committee was disbanded (to be reformed later under a fascist mandate), and the thousands of pages of transcripts were buried for years- only officially made public in the 21st century- the contents of which can be found here with censored testimony in red. https://en.wikisource.org/wiki/McCormack%E2%80%93Dickstein_Committee#endnot… The coup plotters lost no time forming a new organization on August 22, 1934 called the American Liberty League which spent the next decade sabotaging FDR’s New Deal. This group made every effort to promote an American alliance with Axis powers (until 1941’s Pearl Harbor attack), widely financed eugenics, and after FDR died, acted as the driving force behind the McCarthyite police state in America during the Cold War. This deep state coup in America overthrew the FDR/Wallace vision for a post-war anti colonial world order founded upon a US-Russia-China strategic alliance which I illustrated in a recent seminar: http://www.youtube.com/watch?v=1IHVkJPfsx8 ... The Deep State Plot Against JFK The danger of World War and a military coup arose again during the short lived administration of John F. Kennedy who found himself locked in a life or death struggle not with Russia, but with the Military Industrial Complex that had become dominated by the many Dr. Strangeloves of the Joint Chief of Staff and CIA who fanatically believed that America could win a nuclear war with Russia. Kennedy’s valiant efforts to achieve dialogue with his Soviet counterparts, move towards peace in Vietnam, support of colonial liberation, promotion of space exploration and advocacy of a Nuclear Test Ban treaty made him a target of the Deep State of his time. ... This plot was detailed in a quasi-fictional book written by investigative journalists Fletcher Knebel and Charles Bailey published in 1962 entitled Seven Days in May and swiftly made into a famous film with unprecedented support by JFK himself who gave the film crew and director John Frankenheimer full access to the White House, advisors and materials for the film which he believed every American should see. https://risingtidefoundation.net/2019/08/06/rtf-review-of-7-days-in-may/ http://www.youtube.com/watch?v=fRiZtqVPJ9U In the story, a patriotic lieutenant discovers the plans for the coup which is scheduled to take place during a vast military drill whereby a President who is close to finalizing a de-armament treaty with Russia will be incapacitated in a bunker while a military regime takes over America. Tragically, where the lieutenant is able to expose the plot and save the nation in the story, by the time of the film’s 1964 release, JFK had been deposed by other means. Now 56 years later, history has begun to repeat itself with distinctly 21st century characteristics… and a viral twist. https://www.strategic-culture.org/news/2019/11/22/remembering-john-f-kenned… Today, a new systemic meltdown of a $1.5 quadrillion derivatives bubble has similarities to the 1929 crash and other similarities to the 1923 hyperinflation of Weimar. While the coronavirus may or may not be used to trigger this new blowout, one thing is certain: a new fascist coup should be taken more seriously than ever. President Trump’s repeated calls to revive the policies of Abraham Lincoln, end regime change operations and endless wars abroad and work with other sovereign nation states in opposition to world government ideologues is more important than most people realize. https://www.strategic-culture.org/news/2019/11/05/living-under-the-spectre-… So rather than stressing about who might be on the 2020 ballot, it is wiser to ask the question: Where are the General Butlers today?

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[MINISTRY] [FREE SPEECH] [QUESTIONING (((THE NARRATIVE)))] grandma Haverbeck caught, 2 yrs jail
by Zenaan Harkness 06 Dec '20

06 Dec '20

Grandma Haverbeck, who has for 70 odd years been humbly asking for evidence of the hallowed holy gas chambers (like, for example, something OTHER than the rickety wooden pailing-fence gates as the supposed doors of the Auschwitz gas chambers, or any other non refutable evidence for that matter...) went on the lam and the German "authorities" finally caught up with her. 2 years jail begins. https://dailystormer.name/germany-jews-catch-evil-nazi-grandma-who-asked-fo… Germany: Jews Catch Evil Nazi Grandma Who Asked for Evidence of Gas Chambers By the way, the Germans, prior to WW2, did in fact make gas chambers, and made them very firetrucking well thank very firetrucking much - reinforced, hermetically sealed stainless steel "submarine equivalent" doors thank you very much - a far cry from rickety wooden pailing fence gates masquerading as "gas chamber" doors. Good luck Ursula Haverbeck, may God and righteousness be with you. The sane world,

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