Coronavirus: Thread

[jim bell]

 I found a reference that said that the LD50 for rats and ivermectin was 51 milligrams/kilogram.If humans had the same LD50 for ivermectin, a 100 kilogram person's LD50 would be 51 grams.  So, I think it would be safe to take 0.51 grams, or 100x less.  Probably daily.  
                     Jim Bell


    On Monday, December 13, 2021, 10:42:06 PM PST, grarpamp <grarpamp at gmail.com> wrote:  
 
 > ivermectin
>
> https://c19early.com/
> https://covid19criticalcare.com/
> https://flccc.net/
> https://c19adoption.com/
> https://ivmmeta.com/
> https://c19ivermectin.com/
> https://ivmstatus.com/
> https://hcqmeta.com/
> https://c19hcq.com/
> https://c19vitamind.com/
> https://vitamindforall.org/
> https://vdmeta.com/
> https://c19zinc.com/
> https://americasfrontlinedoctors.org/
>
>
> Dying COVID-19 Patient Recovers After Court Orders Hospital To
> Administer Ivermectin


Hospitalizations, Mortality Cut In Half After Brazilian City Offered
Ivermectin To Everyone Pre-Vaccine

https://www.researchgate.net/publication/356962821_Ivermectin_prophylaxis_used_for_COVID-19_reduces_COVID-19_infection_and_mortality_rates_A_220517-subject_populational-level_retrospective_citywide
https://www.thegatewaypundit.com/2021/12/brazilian-city-cuts-hospitalizations-mortality-rates-half-implementing-ivermectin-prophylaxis-covid/
https://twitter.com/sival84/status/1469748843164180481?ref_src=twsrc%5Etfw
https://www.businessinsider.com/brazil-tragic-ivermectin-for-covid-frenzy-warning-to-us-experts-2021-9
https://indianexpress.com/article/cities/lucknow/uttar-pradesh-government-says-ivermectin-helped-to-keep-deaths-low-7311786/
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247163
https://www.medrxiv.org/content/10.1101/2021.01.05.21249310v1
https://journals.sagepub.com/doi/pdf/10.1177/03000605211013550
https://poseidon01.ssrn.com/delivery.php?ID=541021002118114122091103085016081089109025032011016032119087102076096096025065092106001060102005041111018117099069094085119127042034007076000101066091084118012028030084017057102119113099099121007081069085089119026020010091094005103012001080000087113094&EXT=pdf&INDEX=TRUE
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816625/
https://ejmo.org/pdf/A%20Comparative%20Study%20on%20IvermectinDoxycycline%20and%20HydroxychloroquineAzithromycin%20Therapy%20on%20COVID19%20Patients-16263.pdf
https://www.ijidonline.com/article/S1201-9712(20)32506-6/fulltext
https://www.zerohedge.com/covid-19/pfizer-launches-final-study-covid-drug-thats-suspiciously-similar-ivermectin

Early on in the pandemic, before the vaccines were available, the
Southern Brazilian city of Itajai offered Ivermectin as a prophylaxis
against the disease.

Between July and December of 2020, roughly 220,000 people were offered
a dose of 0.2mg/kg/day (roughly 18mg for a 200lb person) as an
optional treatment for 2 days, once every two weeks.

133,051 people took them up on it, while 87,466 did not.

After analyzing the data, a team of researchers spanning several
Brazilian institutes, the University of Toronto, and Columbia's EAFIT
concluded in a December pre-print study that hospitalization and
mortality rates were cut in half over the seven month period among the
Ivermectin group.

    This is even more impressive when you learn the IVM users were
older on average, with 30% >50 yo versus 20% for non-IVM users. The
mortality reduction is even higher looking at different age groups.
85% for 31-49 yo and 59% for >50 yo. pic.twitter.com/K6D5naybCS
    — Simon Vallée (@sival84) December 11, 2021

The authors adjusted for relevant confounding variables, including
age, sex, medical history, previous diseases, and other conditions.

The analysis contradicts an October report by Business Insider which
claims, based on a Brazilian ICU doctor's anecdotal evidence, that the
experiment was a failure.

Study limitations:

The authors note, "Being a retrospective observational analysis, it is
uncertain whether results would be reproducible in a randomized,
placebo-controlled, double-blind clinical trial, but likely, since
groups of ivermectin users and non-users had  similar demographic
characteristics, and rates were adjusted for the relevant confounding
variables."

We're sure the 'fact checkers' are already hard at work trying to
debunk the pre-print, however they may also want to take a look at
ivmmeta.com - a real-time meta analysis of 70 studies which found that
Ivermectin works as a prophylaxis 83% of the time. In peer-reviewed
studies, it was found effective 70% of the time as an early treatment,
and just 39% of the time as a late treatment.

As we noted during the whole 'horse paste' controversy:

Ivermectin

This widely prescribed anti-parasitic which is also used in horses has
shown meaningful efficacy worldwide in the treatment of mild and
moderate cases of Covid-19, plus as a prophylactic. India's Uttar
Pradesh province, with a population of over 200 million, says that
widespread early use of Ivermectin 'helped keep positivity [and]
deaths low.'
(source, May 12th)

Separately, there have been several studies funded by the Indian
government, primarily conducted through their largest govt. public
medical university (AIIMS).

    Role of ivermectin in the prevention of SARS-CoV-2 infection among
healthcare workers in India: A matched case-control study (source)

    Conclusion: Two-dose ivermectin prophylaxis at a dose of 300 μg/kg
with a gap of 72 hours was associated with a 73% reduction of
SARS-CoV-2 infection among healthcare workers for the following month.

    Ivermectin as a potential treatment for mild to moderate COVID-19
– A double blind randomized placebo-controlled trial (source)

    Conclusion: There was no difference in the primary outcome i.e.
negative RT-PCR status on day 6 of admission with the use of
ivermectin. However, a significantly higher proportion of patients
were discharged alive from the hospital when they received ivermectin.

    Clinical Research Report Ivermectin in combination with
doxycycline for treating COVID-19 symptoms: a randomized trial
(source, double-blind randomized, peer-reviewed)

    Discussion: In the present study, patients with mild or moderate
COVID-19 infection treated with ivermectin in combination with
doxycycline generally recovered 2 days earlier than those treated with
placebo. The proportion of patients responding within 7 days of
treatment was significantly higher in the treatment group than in the
placebo group. The proportions of patients who remained symptomatic
after 12 days of illness and who experienced disease progression were
significantly lower in the treatment group than in the placebo group.

Here are more human studies from other countries on the 'horse dewormer':

Peru:

    Sharp Reductions in COVID-19 Case Fatalities and Excess Deaths in
Peru in Close Time Conjunction, State-By-State, with Ivermectin
Treatments (source, peer-reviewed, University of Toronto, Universidad
EAFIT)

    For the 24 states with early IVM treatment (and Lima), excess
deaths dropped 59% (25%) at +30 days and 75% (25%) at +45 days after
day of peak deaths. Case fatalities likewise dropped sharply in all
states but Lima

Spain:

    The effect of early treatment with ivermectin on viral load,
symptoms and humoral response in patients with non-severe COVID-19: A
pilot, double-blind, placebo-controlled, randomized clinical trial
(source, University of Barcelona, peer-reviewed)

    Findings: Patients in the ivermectin group recovered earlier from
hyposmia/anosmia (76 vs 158 patient-days; p < 0.001).

Bengladesh:

    A Comparative Study on Ivermectin-Doxycycline and
Hydroxychloroquine-Azithromycin Therapy on COVID-19 Patients (source -
peer reviewed, though not govt funded)

    Conclusion: According  to  our  study,  the
Ivermectin-Doxycycline combination therapy has better symptomatic
relief, shortened recovery duration, fewer adverse effects, and
superior patient compliance compared to the
Hydroxychloroquine-Azithromycin combination. Based on this  study's
outcomes,  the  Ivermectin-Doxycycline  combination  is  a  superior
choice  for  treating  patients  with  mild to moderate COVID-19
disease.

    A five-day course of ivermectin for the treatment of COVID-19 may
reduce the duration of illness (source, peer-reviewed double blind
randomized, though small sample size)

    Discussion: A 5-day course of ivermectin resulted in an earlier
clearance of the virus compared to placebo (p = 0.005), thus
indicating that early intervention with this agent may limit viral
replication within the host. In the 5-day ivermectin group, there was
a significant drop in CRP and LDH by day 7, which are indicators of
disease severity.

Why does Ivermectin, a 'horse dewormer' work? For starters, it's a
protease inhibitor. Interestingly, Pfizer's 2x/day Covid-19
prophylactic they're trialing right now is also a protease inhibitor.

Perhaps the most damning evidence in favor of Ivermectin is the
medical establishment's position that it's essentially snake oil,
despite the fact that it's had a glowing safety profile for decades,
until now.
  
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