Assuming this was actually a miracle treatment for covid, that was safe, inexpensive, and widely available. Can someone help me understand why the global health community wouldn't have embraced it? Is the theory that there is some kind of global conspiracy to keep people ill intentionally? David On Fri, Sep 3, 2021, 11:12 AM jim bell <jdb10987@yahoo.com> wrote:

On Friday, September 3, 2021, 08:46:16 AM PDT, professor rat < pro2rat@yahoo.com.au> wrote:

...

Oklahoma's ERs are so backed up with people overdosing on ivermectin that gunshot victims are having to wait to be treated, a doctor says <https://www.insider.com/oklahomas-emergency-rooms-are-clogged-with-people-overdosing-on-ivermectin-2021-9>

Jim Bell's comment:

My reaction is that the reason they are 'overdosing on Ivermectin' is that they aren't being told what the proper dosage is. I considered this question after I had bought 12 tubes of this, long before I was fully vaccinated on April 3, 2021. I had no intention of taking it, at least not until the possible day I knew I was getting sick. But I figured that this drug would, soon enough, become so well-known that it would be unavailable. And I was not going to delay acquiring it.

And though they use the term "overdose", we can reasonably wonder what they really mean by that. Were there any negative consequences? In part, I ask because these people may already be sick, of COVID, and they presumably don't know the difference between "getting COVID-19" and "getting COVID-19 AND having an 'overdoze' of Ivermectin."

I also acquired bottles of a drug called "Famotidine", which also made only a tiny splash as an anti-COVID-19 drug, again long before I was vaccinated. I found it up on the top shelf at the local Walmart.

https://clinicaltrials.gov/ct2/show/NCT04504240

It's sold under the brand name Pepcid. Famotidine (Pepcid): Side Effects, Dosages, Treatment, Interactions, Warnings <https://www.rxlist.com/consumer_famotidine_pepcid/drugs-condition.htm>

I informed this list of famotidine April 30, 2020:

======================= jim bell <jdb10987@yahoo.com> To:CypherPunks Thu, Apr 30, 2020 at 9:44 AM Famotidine: This drug, normally used as an ant-acid ("Pepcid") is being talked about recently.

Heartburn drug trial shows 'reasonable confidence' famotidine could help treat coronavirus, hospital CEO says <https://www.cnbc.com/2020/04/28/heartburn-drug-trial-shows-reasonable-confidence-famotidine-could-help-treat-coronavirus-hospital-ceo-says-.html?__twitter_impression=true&recirc=taboolainternal>

Heartburn drug trial shows 'reasonable confidence' famotidine could help...

Noah Higgins-Dunn

Northwell Health CEO Michael Dowling said it's too early to say definitively whether it works, but "our scientis...

<https://www.cnbc.com/2020/04/28/heartburn-drug-trial-shows-reasonable-confidence-famotidine-could-help-treat-coronavirus-hospital-ceo-says-.html?__twitter_impression=true&recirc=taboolainternal> =============================

Yes, I found the answer on the dose of Ivermectin, but I had to do a google search for the details, and then had to calculate how much of this material to use. All that wasn't hard, but then again I have a degree in chemistry.

I also think they are deliberately misusing the term "overdose". Ordinarily, and for laymen, "overdose" means a dose that has negative consequences, possibly severe. I think the biased MSM is simply trying to scare people away from using Ivermectin. I have heard that Ivermectin does indeed have a valid human use, but that proper dosage is not necessarily sufficient to treat COVID-19. But, even that dosage probably does not have any negative consequences. But unless people know what that dosage is, they will potentially take a too-high dose. If the medical establishment was actually well-meaning, they would help the public to not take more than a harmful amount. But they aren't, so they don't.

I have no doubt that there is SOME dosage that will have negative consequences, but I suspect that dosage is far above any needed value. The proper handling of this question, I think, is for the medical establishment to publicize the dosage level at which Ivermectin becomes actually harmful, and put it in terms that a typical non-technical person might use. It might involve some calculation, based on the weight of a person.

Why Has "Ivermectin" Become a Dirty Word? <https://taibbi.substack.com/p/why-has-ivermectin-become-a-dirty-7bd?token=eyJ1c2VyX2lkIjo5NTQ5NTQxLCJwb3N0X2lkIjozNzc0NjMxMiwiXyI6IlBYMEFFIiwiaWF0IjoxNjI0MTEzMDAzLCJleHAiOjE2MjQxMTY2MDMsImlzcyI6InB1Yi0xMDQyIiwic3ViIjoicG9zdC1yZWFjdGlvbiJ9.cHzKKj_ES3lsD6_mnIl7RZYlg7X2ypDbP7GP5gn8844>

Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines - PubMed <https://pubmed.ncbi.nlm.nih.gov/34145166/>

Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systema...

Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. Using ... <https://pubmed.ncbi.nlm.nih.gov/34145166/>

From that:

19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines Andrew Bryant <https://pubmed.ncbi.nlm.nih.gov/?term=Bryant+A&cauthor_id=34145166> 1 <https://pubmed.ncbi.nlm.nih.gov/34145166/#affiliation-1>, Theresa A Lawrie <https://pubmed.ncbi.nlm.nih.gov/?term=Lawrie+TA&cauthor_id=34145166> 2 <https://pubmed.ncbi.nlm.nih.gov/34145166/#affiliation-2>, Therese Dowswell <https://pubmed.ncbi.nlm.nih.gov/?term=Dowswell+T&cauthor_id=34145166> 2 <https://pubmed.ncbi.nlm.nih.gov/34145166/#affiliation-2>, Edmund J Fordham <https://pubmed.ncbi.nlm.nih.gov/?term=Fordham+EJ&cauthor_id=34145166> 2 <https://pubmed.ncbi.nlm.nih.gov/34145166/#affiliation-2>, Scott Mitchell <https://pubmed.ncbi.nlm.nih.gov/?term=Mitchell+S&cauthor_id=34145166> 3 <https://pubmed.ncbi.nlm.nih.gov/34145166/#affiliation-3>, Sarah R Hill <https://pubmed.ncbi.nlm.nih.gov/?term=Hill+SR&cauthor_id=34145166> 1 <https://pubmed.ncbi.nlm.nih.gov/34145166/#affiliation-1>, Tony C Tham <https://pubmed.ncbi.nlm.nih.gov/?term=Tham+TC&cauthor_id=34145166> 4 <https://pubmed.ncbi.nlm.nih.gov/34145166/#affiliation-4> Affiliations expand

- PMID: 34145166 - PMCID: PMC8248252 <http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8248252/> - DOI: 10.1097/MJT.0000000000001402 <https://doi.org/10.1097/mjt.0000000000001402>

Free PMC article Abstract

*Background: *Repurposed medicines may have a role against the SARS-CoV-2 virus. The antiparasitic ivermectin, with antiviral and anti-inflammatory properties, has now been tested in numerous clinical trials.

*Areas of uncertainty: *We assessed the efficacy of ivermectin treatment in reducing mortality, in secondary outcomes, and in chemoprophylaxis, among people with, or at high risk of, COVID-19 infection.

*Data sources: *We searched bibliographic databases up to April 25, 2021. Two review authors sifted for studies, extracted data, and assessed risk of bias. Meta-analyses were conducted and certainty of the evidence was assessed using the GRADE approach and additionally in trial sequential analyses for mortality. Twenty-four randomized controlled trials involving 3406 participants met review inclusion.

*Therapeutic advances: *Meta-analysis of 15 trials found that ivermectin reduced risk of death compared with no ivermectin (average risk ratio 0.38, 95% confidence interval 0.19-0.73; n = 2438; I2 = 49%; moderate-certainty evidence). This result was confirmed in a trial sequential analysis using the same DerSimonian-Laird method that underpinned the unadjusted analysis. This was also robust against a trial sequential analysis using the Biggerstaff-Tweedie method. Low-certainty evidence found that ivermectin prophylaxis reduced COVID-19 infection by an average 86% (95% confidence interval 79%-91%). Secondary outcomes provided less certain evidence. Low-certainty evidence suggested that there may be no benefit with ivermectin for "need for mechanical ventilation," whereas effect estimates for "improvement" and "deterioration" clearly favored ivermectin use. Severe adverse events were rare among treatment trials and evidence of no difference was assessed as low certainty. Evidence on other secondary outcomes was very low certainty. *Conclusions: *Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. Using ivermectin early in the clinical course may reduce numbers progressing to severe disease. The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally.

*============end of quote=================*

Notice that I informed this list, Cypherpunks, of Ivermectin and its potential use against COVID-19 on April 3, 2020, which is by coincidence one year before I received by second Pfizer COVID-

jim bell <jdb10987@yahoo.com> To:CypherPunks Fri, Apr 3, 2020 at 6:28 PM

https://futurism.com/neoscope/anti-parasitic-drug-kills-coronavirus-cell-cul...

A team of Australian researchers at Monash University in Melbourne have found that Ivermectin — an FDA-approved anti-parasitic drug that has been used to effectively fight viruses including HIV, Influenza, and Zika — was able to stop the SARS-CoV-2 virus from growing in cell cultures.

While promising, the drug has yet to be shown to have the same effect inside the human body, because the Australian research was conducted “in vitro,” meaning it was in a Petri dish at a lab. The researchers are still trying to nail down funding for pre-clinical testing and clinical trials, after which they’d have to start the long approval process for the trials themselves.

The results, though, are promising. In just 48 hours, the scientists say, all genetic material of the virus was eradicated.

“We found that even a single dose could essentially remove all viral RNA by 48 hours and that even at 24 hours there was a really significant reduction in it,” Kylie Wagstaff, lead researcher and co-author of the study published today in Antiviral Research, said in a statement.

“Ivermectin is very widely used and seen as a safe drug,” Wagstaff said. “We need to figure out now whether the dosage you can use it at in humans will be effective — that’s the next step.”

“As the virologist who was part of the team who were first to isolate and share SARS-COV2 outside of China in January 2020, I am excited about the prospect of Ivermectin being used as a potential drug against COVID-19,” Leon Caly, senior medical scientist at the Victorian Infectious Diseases Reference Laboratory (VIDRL) at the Doherty Institute, said.

A vaccine for COVID-19 is likely still at least a year out, despite research teams across the world fast tracking work on potential vaccines. But that doesn’t mean we’re doomed.

“In times when we’re having a global pandemic and there isn’t an approved treatment, if we had a compound that was already available around the world then that might help people sooner,” Wagstaff said in the statement. “Realistically it’s going to be a while before a vaccine is broadly available.”

----------------------------------- Oops! I Just Took My Dog's Heartworm Medicine<br /> <https://www.poison.org/articles/ivermectin-your-dogs-heartworm-medicine-173>

The Full Story

Sometimes new drugs are found in unusual places. The antiparasitic drug ivermectin was discovered in the 1970s in bacteria isolated from the soil on a Japanese golf course. Ivermectin was called the first "endectocide" since it was active against both endoparasites (parasites that live inside the host) and ectoparasites (parasites that live on the outside of the host).

Ivermectin was initially developed as a veterinary antiparasitic drug. Of particular importance today is ivermectin's ability to prevent heartworm infections in dogs with monthly dosing (e.g., Heartgard). Ivermectin has also protected hundreds of millions of livestock from a variety of parasites.

Ivermectin lotion is approved by the FDA for the treatment of head lice. Unlike many other treatments for head lice, ivermectin lotion only needs to be applied once. When given orally, ivermectin can be used for treating head or pubic lice and scabies (an itchy, highly contagious skin disease caused by mites burrowing in the skin). Oral ivermectin is useful to control outbreaks of scabies in nursing homes where whole-body application of topical agents is difficult.

Ivermectin's greatest impact on human health has been in Africa. Since 1987, in addition to its use for other parasitic infestations, ivermectin has been used extensively to control onchocerciasis with 1.4 billion treatments so far. Onchocerciasis is also called "river blindness" because the blackfly that transmits the disease breeds in fast-moving streams and rivers. Once within the body, the adult female worm produces thousands of juvenile worms that migrate to the skin and eyes and can produce severe itching and eye injury that can lead to blindness.

Ivermectin kills the juvenile worms, but not the adult females. The effectiveness of the drug lasts up to 12 months, but mature female worms produce offspring for 15 years, so ivermectin has to be taken once a year for that long.

Over 300 million people take ivermectin each year. To date, ivermectin has been shown to be a safe and well-tolerated drug. Most adverse reactions are mild and temporary, such as loss of appetite, headache, muscle aches, lack of energy, and fever. There have been a small number of severe adverse events and even some deaths in humans treated with ivermectin in onchocerciasis-control programs. The reason for these events is unknown, but they might be linked to the presence of large numbers of other parasites that are killed off in treated patients.

If you suspect someone has swallowed ivermectin, do not make the person vomit. Immediately check the webPOISONCONTROL® online tool for help or call Poison Control at 1-800-222-1222.

When ivermectin gets in the eyes, minor irritation and redness can occur. Serious eye injury is not likely, but the eyes should be rinsed immediately. Remove contact lenses and use lots of room temperature water. For children, pour water onto the bridge of the nose and let it gently run into the eyes. Encourage blinking. After rinsing, call Poison Control or use the webPOISONCONTROL tool for help.

Mary Elizabeth May, RN, BA, MPH Certified Specialist in Poison Information

Oops! I Just Took My Dog's Heartworm Medicine<br />

Ivermectin is a beneficial and safe antiparasitic drug used for a wide variety of parasitic diseases in humans a...

<https://www.poison.org/articles/ivermectin-your-dogs-heartworm-medicine-173>