Ambitious appeal The Global Fund to Fight AIDS, Tuberculosis and Malaria <https://t.devex.com/Njg1LUtCTC03NjUAAAGYx15_qzFd9l2OZTY235few0UuXDY6zNV3m8GhoHja3cU13tyhQ9q44z6b9gSB7T4rDXKPz1c=> is *aiming to raise $18 billion to continue its critical work*. A fully funded Global Fund “could save an additional 23 million lives between 2027 and 2029.” Executive Director Peter Sands highlighted the fund’s high return on investment, stating that “for every dollar invested in the Global Fund, they expect a return of $19 in health and economic benefits.” South Africa and the United Kingdom will cohost the replenishment effort, but raising the full amount won’t be easy <https://t.devex.com/dc/kyXVoDpAY__Vu56MNr4POp1mn9lW8gJ-vTpus1F37TLIkvgQud02q_-xISDaW8eOGGkOOWbEPztLg_hJCgVVcPr7qRbjhN_xXj66dhPpKpWOsEf6Nw-SBWvJDbY2_4mtwdW8Oj64j5l8X4PCnDxhxtspE2_JMwi6PAxJdJWjg3BfuvHf2XbxDfpbNPGPnBxlNX_w00M-BHyBCrA1ne08xT9rtIFk-5jlOP2DTcQXXPeyQFrLTXylQy-JZd0kGvcMAI_QOQ8494_x4H8vhOOa4g==/Njg1LUtCTC03NjUAAAGYx15_q8rmEppOfm-4enZ-07ZU0SrFywJBdDr5Na0c-niDgUmW0TITioKeX7vCzPgnJbdB3fM=>, writes Devex Senior Reporter Jenny Lei Ravelo. The ask *comes amid donor fatigue and a U.S. aid funding freeze* that has already forced global health programs, including those tackling HIV, TB, and malaria, to shut down. “This would be a record breaking replenishment, which would be surprising, given reduced interest in global health from major donors,” says Pete Baker, deputy director of the global health policy program at the Center for Global Development <https://t.devex.com/Njg1LUtCTC03NjUAAAGYx15_q1O_VotomMlacJWcBLqaXdKmmT9B_qHE9aREHgfBQvexDUmxHTYS8tkv81T_80EGulc=> . The fund also leans heavily on *U.S. support, which makes up about 30% of its funding*. “The US simultaneous retreat from aid, reproductive health and multilateralism, should be concerning for the size of its future commitment [to] the Global Fund,” Baker warns. With fundraising uncertainty ahead, the Global Fund’s ambitious goal may be a tough sell — but with millions of lives on the line, advocates say the stakes couldn’t be higher. *Read:* Global Fund launches $18B replenishment in tough fundraising landscape <https://t.devex.com/dc/kyXVoDpAY__Vu56MNr4POp1mn9lW8gJ-vTpus1F37TLIkvgQud02q_-xISDaW8eOGGkOOWbEPztLg_hJCgVVcPr7qRbjhN_xXj66dhPpKpWOsEf6Nw-SBWvJDbY2_4mtwdW8Oj64j5l8X4PCnDxhxtspE2_JMwi6PAxJdJWjg3BfuvHf2XbxDfpbNPGPnBxlNX_w00M-BHyBCrA1ne08xT9rtIFk-5jlOP2DTcQXXPeyQFrLTXylQy-JZd0kGvcMloTQDIy7Bbk5onTeJejv3Q==/Njg1LUtCTC03NjUAAAGYx15_q8rmEppOfm-4enZ-07ZU0SrFywJBdDr5Na0c-niDgUmW0TITioKeX7vCzPgnJbdB3fM=>