On 03/26/2017 08:43 AM, \0xDynamite, an intellectual 'hole' into which people throw their time responding, repied to John Newman's factual statement:

NOT THAT IT MATTERS, but Prozac is in fact ananti-depressant.

With:

You mean not that it matters, because you don't have a way to argue
out of your own hole, so "repeat what I already said tactic here".


Fact:

The effectiveness of fluoxetine and other antidepressants in the treatment of mild-to-moderate depression is controversial. A meta-analysis published by Kirsch in 2008 suggests, in those with mild or moderate symptoms, the efficacy of fluoxetine and other SSRIs is clinically insignificant...


Lilly originally redacted a little bit in their study that showed a placebo, when given by a trusted health worker with the admonishment "Try this. It will help", worked as well as "Prozac" does.


A paper on antidepressants by Kirsch and co-authors published last month in PLoS Medicine has received a lot of attention. The antidepressants studied are the six most widely prescribed approved between 1987 and 1999: Prozac, Paxil, Effexor, Serzone, Zoloft, and Celexa.

The Editors' Summary explains:

    The researchers obtained data on all the clinical trials submitted to the FDA ... They then used meta-analytic techniques to investigate whether the initial severity of depression affected the HRSD [Hamilton Rating Scale for Depression] improvement scores for the drug and placebo groups in these trials. They confirmed first that the overall effect of these new generation of antidepressants was below the recommended criteria for clinical significance. Then they showed that there was virtually no difference in the improvement scores for drug and placebo in patients with moderate depression and only a small and clinically insignificant difference among patients with very severe depression.

The difference in improvement between the antidepressant and placebo reached clinical significance, however, in patients with initial HRSD scores of more than 28—that is, in the most severely depressed patients.

Additional analyses indicated that the apparent clinical effectiveness of the antidepressants among these most severely depressed patients reflected a decreased responsiveness to placebo rather than an increased responsiveness to antidepressants.

The press simplified it further. The MSNBC headline was "Antidepressants may not help many patients". The Guardian announced: "Prozac, used by 40m people, does not work say scientists".

In Full, with charts, graphs, and statistical analyses: http://logbase2.blogspot.com/2008/03/upping-anti-depressant.html

Marijuana works to relieve what can only be described as "Social Anxiety" (which is Zoloft's target market btw, singling out women) for MANY people, unlike the so-called ANTIDEPRESSANT Prozac ... and marijuana isn't even a drug. It's an herb, 'holistic boy'. Unless you think Comfrey, Sassafras, and the raft of other herbs you lernt about in assholistic skool are 'drugs' ... because they contain therapeutic ingredients.

That said, "\0xDynamite" added to my spamcan list.

Rr