Sampo A Syreeni <ssyreeni@cc.helsinki.fi> writes:
On Fri, 1 Sep 2000, David Marshall wrote:
Not to mention that there exists a certain peptide, the name of which escapes me at the moment, which is naturally occuring in the brain. It is five amino acids long, and exerts an effect about 5000 times stronger than that of Heroin. There are far more where that came from.
Of course. Just as there is anandamide, the transmitter which hemp compounds mainly mimic. Only you do not easily get such substances into the brain without using a needle - proteins generally do not get through the blood-brain barrier absent active transport. So you would need proteins which, after somehow having been delivered in the blood stream whole, are actively transported (this means extra 'handles' so that the molecule is recognized) across the barrier, then we probably need a working mechanism which then processes (cleaves, oxidises etc.) to obtain a final active compound. All in all, you do not easily deliver proteins to the brain.
Yes, I know that. The point, though, was that the war on drugs is futile and is about to be made worse. If you think our freedoms are compromised for the War on (some) Drugs now, just wait fifteen years. On the topic of the blood-brain barrier, another example is compounds such as cocaine, which exist in charged and uncharged forms. Normally, the ratio is something like 99:1, so it takes some time for the entire dose to actually get into the brain where it can do something. Crack cocaine is made using a relatively simple procedure which changes that equilibrium to where almost all of it blows into the brain at once. This is why crack cocaine is considered worse than the "regular" powder. Societies -- and American society in particular -- seem to loathe actually fixing problems. We find secondary or tertiary (or worse) symptoms, and try to treat those. This is partially because fixing the real roots of the problem also affects other things, makes some of the American people accept responsibility for some things, and is suicide to a politician. This doesn't work, of course. It's like giving someone with chronic headaches, vertigo, and dementia some asprin and psychoactive drugs; it masks the symptoms, but doesn't fix the problem, which might be a brain tumor.
On Sun, 3 Sep 2000, David Marshall wrote:
Crack cocaine is made using a relatively simple procedure which changes that equilibrium to where almost all of it blows into the brain at once. This is why crack cocaine is considered worse than the "regular" powder.
'Freebasing' wasn't it? Cook in high pH to release the free alcaloid form from the salt. What I do not remember is the precise reason for the high permeability - water solubility? Sampo Syreeni <decoy@iki.fi>, aka decoy, student/math/Helsinki university
If I remember correctly - the formula is simple enough. 1 part (unit) cocain for every 10 parts (units) of baking soda. Mix well - add water until you have a paste - then smear past on flat baking pan - place in oven until mixture hardens (no I don't remember the temperture one uses - but it would be somewhere between 200 - 300 F). When the mixture hardens - you let it cool to room temputer and then hit it with a hammer to break it up - and viola - you have crack cocain - the most evil substance on the planet. regards Joe Baptista http://www.dot-god.com/ dot.GOD Hostmaster On Mon, 4 Sep 2000, Sampo A Syreeni wrote:
On Sun, 3 Sep 2000, David Marshall wrote:
Crack cocaine is made using a relatively simple procedure which changes that equilibrium to where almost all of it blows into the brain at once. This is why crack cocaine is considered worse than the "regular" powder.
'Freebasing' wasn't it? Cook in high pH to release the free alcaloid form from the salt. What I do not remember is the precise reason for the high permeability - water solubility?
Sampo Syreeni <decoy@iki.fi>, aka decoy, student/math/Helsinki university
At 04:17 PM 9/3/00 -0400, David Marshall wrote:
On the topic of the blood-brain barrier, another example is compounds
There's also a trick where you can add an acetyl group to a small molecule (not protein) to increase transport. Do it to salicylic acid, you get aspirin. Do it to morphine, you get heroin. FWIW
participants (4)
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!Dr. Joe Baptista -
David Honig -
David Marshall -
Sampo A Syreeni