Eugen is right, the drones are targeted by coodinates not by sight. Sight (or video) is used to spot the target, then the target's coordinates are input to the data collection, then the operator extracts the coordinates to aim the missile, then the missile takes over. The drone may have moved several miles away by then but the missile will hammer to the coordinates. Time delay makes no difference. Sometimes the target;s coordinates are triangulated by one or more drones, and maybe confirmation by a satellite, to refine the coordinates for a smaller hit circle. But that is done only if the target is stationary, one on the move may be targeted very quickly, and tracked visually to confirm the hit, to cheers in the USA. These visual assassinations are what gives hard-ons at CIA HQ (and wherever else they are piped to), sometimes shown during lunch at the director's private dining room, 7th floor corner suite -- the kitchen's ventilation ducts and burn-bag chimney adjacent make a nice target for payback. Imagine the surprise if a counter or rogue drone did at Langley what they do in AFPAK to people watching TV over dinner. There do not appear to be anti-missile batteries at Langley like those in DC and MD to protect POTUS aircraft. Could be they are obscured in the public sat photos. More likely security by obscurity is trumped by vanity that nobody could do what the US does, well, excepting 9/11.